Mofarotene (Ro 40-8757) inhibits hematopoiesis in vitro by preventing maturation from primitive progenitor cells.

@article{Eliason1995Mofarotene4,
  title={Mofarotene (Ro 40-8757) inhibits hematopoiesis in vitro by preventing maturation from primitive progenitor cells.},
  author={James F. Eliason and Magdalena Baumgartner and Takashi Yoshikubo and Yoko Hirabayashi and Hideki Mitsui and Tohru Inoue},
  journal={Blood},
  year={1995},
  volume={86 12},
  pages={4516-26}
}
The effect of the arotinoid mofarotene (Ro 40-8757; 4-[2-[p-[(E)- 2(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)- propenyl]phenoxy]ethyl]morpholine) on stromal cell-mediated hematopoiesis was examined in murine long-term bone marrow cultures. Whether added at week 2 to regenerating cultures or at week 4 to plateau-phase cultures, mofarotene strongly… CONTINUE READING