Moesin and myosin phosphatase confine neutrophil orientation in a chemotactic gradient

@inproceedings{Liu2015MoesinAM,
  title={Moesin and myosin phosphatase confine neutrophil orientation in a chemotactic gradient},
  author={Xiaowen Liu and Tao H. Yang and Koya Suzuki and Sachiko Tsukita and Masaru Ishii and Shuping Zhou and Gang Sam Wang and Luyang Cao and Feng Qian and Shalina Taylor and Myung-Jin Oh and Irena Levitan and Richard D Ye and Graeme K. Carnegie and Yong Zhao and Asrar B. Malik and Jingsong Xu},
  booktitle={The Journal of experimental medicine},
  year={2015}
}
Neutrophils respond to invading bacteria by adopting a polarized morphology, migrating in the correct direction, and engulfing the bacteria. How neutrophils establish and precisely orient this polarity toward pathogens remains unclear. Here we report that in resting neutrophils, the ERM (ezrin, radixin, and moesin) protein moesin in its active form (phosphorylated and membrane bound) prevented cell polarization by inhibiting the small GTPases Rac, Rho, and Cdc42. Attractant-induced activation… CONTINUE READING

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