Moesin Controls Cortical Rigidity, Cell Rounding, and Spindle Morphogenesis during Mitosis

@article{Kunda2008MoesinCC,
  title={Moesin Controls Cortical Rigidity, Cell Rounding, and Spindle Morphogenesis during Mitosis},
  author={Patricia Kunda and Andrew E. Pelling and Tao Liu and Buzz Baum},
  journal={Current Biology},
  year={2008},
  volume={18},
  pages={91-101}
}
BACKGROUND During mitosis, animal cells undergo a complex sequence of morphological changes, from retraction of the cell margin and cell rounding at the onset of mitosis to axial elongation and cytokinesis at mitotic exit. The molecular mechanisms driving the early changes in mitotic cell form and their functional significance, however, remain unknown. Here we identify Moesin as a key player. Moesin is the sole Drosophila member of the ERM proteins, which, once activated via phosphorylation… CONTINUE READING
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Get round and stiff for mitosis.

HFSP journal • 2008
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Mitosis: Moesin and the Importance of Being Round

Current Biology • 2008
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