Module dynamics of the GnRH signal transduction network.

  title={Module dynamics of the GnRH signal transduction network.},
  author={David C. Krakauer and Karen M. Page and Stuart C. Sealfon},
  journal={Journal of theoretical biology},
  volume={218 4},
We analyse computational modules of a frequency decoding signal transduction network. The gonadotropin releasing hormone (GnRH) signal transduction network mediates the biosynthesis and release of the gonadotropins, luteinizing hormone (LH) and follicle stimulating hormone (FSH). The pulsatile pattern of GnRH production by the hypothalamus has a critical influence on the release and synthesis of gonadotropins in the pituitary. In humans, slower pulses lead to the expression of the beta-subunit… CONTINUE READING