Modulatory role of ERK MAPK-caldesmon pathway in PDGF-stimulated migration of cultured pulmonary artery SMCs.

@article{Yamboliev2001ModulatoryRO,
  title={Modulatory role of ERK MAPK-caldesmon pathway in PDGF-stimulated migration of cultured pulmonary artery SMCs.},
  author={Ilia A. Yamboliev and William T. Gerthoffer},
  journal={American journal of physiology. Cell physiology},
  year={2001},
  volume={280 6},
  pages={
          C1680-8
        }
}
Extracellular signal-regulated kinase (ERK) mitogen-activated protein kinases (MAPKs) phosphorylate caldesmon in vivo, but the function of caldesmon phosphorylation in smooth muscle physiology is controversial. We hypothesized that ERK MAPKs and caldesmon modulate chemotactic migration of cultured canine pulmonary artery smooth muscle cells (PASMCs). Platelet-derived growth factor (PDGF; 10 ng/ml) and endothelin-1 (ET-1; 100 nM) transiently activated ERK MAPKs: PDGF produced higher maximal and… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

Galectin-3 mediates the effect of PDGF on pulmonary arterial hypertension.

International journal of clinical and experimental medicine • 2015
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 30 references

Regulation of Cell Motility by Mitogen-activated Protein Kinase

The Journal of cell biology • 1997
View 7 Excerpts
Highly Influenced

Phosphorylation of caldesmon by ERK MAP kinases in smooth muscle.

American journal of physiology. Cell physiology • 2000
View 2 Excerpts

Similar Papers

Loading similar papers…