Modulatory functions of neurotransmitters in the striatum: ACh/dopamine/NMDA interactions

  title={Modulatory functions of neurotransmitters in the striatum: ACh/dopamine/NMDA interactions},
  author={Gaetano di Chiara and Micaela Morelli and Silvana Consolo},
  journal={Trends in Neurosciences},

The cholinergic system and neostriatal memory functions

Synaptic integration mediated by striatal cholinergic interneurons in basal ganglia function.

The physiological role of striatal cholinergic interneurons was investigated with immunotoxin-mediated cell targeting and showed that the acetylcholine-dopamine interaction is concertedly and adaptively regulated for basal ganglia synaptic integration.

University of Groningen The cholinergic system and neostriatal memory functions

The current knowledge and new findings indicate that the cholinergic system in the striatum is involved in a diverse set of cognitive functions through interactions with other neurotransmitter systems including the dopaminergic and GABAergic systems.

Dopamine - Acetylcholine interactions

Dopamine-acetylcholine interactions can take place within and outside the striatum, where cholinergic neurons receive direct excitatory glutamatergic inputs from the cortex and in particular from the parafascicular thalamus.

Dopamine and N-Methyl-D- Aspartate Receptor Interactions in the Neostriatum

This review examines dopamine (DA) and glutamate receptor interactions in the neostriatum (NS) primarily from a neurophysiological perspective and the functional implications of this model in setting membrane potentials, signal-to-noise ratio, plasticity and excitotoxicity are discussed.

Striatal and extrastriatal dopamine in the basal ganglia: An overview of its anatomical organization in normal and Parkinsonian brains

  • Y. SmithR. Villalba
  • Biology, Psychology
    Movement disorders : official journal of the Movement Disorder Society
  • 2008
The importance and specificity of dopamine in regulating morphological changes in striatal projection neurons provides further evidence for the complex and multifarious mechanisms through which dopamine mediates its functional effects in the basal ganglia.



Neurotransmitters and neuromodulators in the basal ganglia

  • A. Graybiel
  • Biology, Psychology
    Trends in Neurosciences
  • 1990

Modulatory actions of neurotransmitters.

  • I. Kupfermann
  • Biology, Psychology
    Annual review of neuroscience
  • 1979
While there is no necessary connection between behavioral modulation and neural modulation, the available evidence from invertebrates suggests that there often is a connection.

Extrinsic connections of the basal ganglia

Cholinergic and dopaminergic modulation of potassium conductances in neostriatal neurons.

The nature of the muscarinic modulation of the Af current suggests that acetylcholine should not be viewed as excitatory or inhibitory but rather as enhancing state stability, and provides a basis on which dopamine might interact with acetyl choline in controlling neostriatal excitability.

Release-regulating D-2 dopamine receptors are located on striatal glutamatergic nerve terminals.

The data represent a direct demonstration that receptors sensitive to nanomolar concentrations of DA and belonging to the D-2 type are located on GLU axon terminals in the rat corpus striatum where they may modulate the release of GLU from glutamatergic afferents including the cortico-striatal pathway.

Fos Immunoreactivity after Stimulation or Inhibition of Muscarinic Receptors Indicates Anatomical Specificity for Cholinergic Control of Striatal Efferent Neurons and Cortical Neurons in the Rat

Cholinergic neurons play a major role in the control of striatal activity via muscarinic receptors. The action of acetylcholine also appears to be dependent on the striosome – matrix

Dopaminergic regulation of striatal acetylcholine release: importance of D1 and N-methyl-D-aspartate receptors.

The results indicate that d-amphetamine increases ACh release in the striatum via a D1 receptor mechanism and local application of CY 208-243 and SCH 23390 failed to alter ACh concentrations in thestriatal dialysate.