Modulatory effects of sCD14 and LBP on LPS-host cell interactions.

  title={Modulatory effects of sCD14 and LBP on LPS-host cell interactions.},
  author={Richard L. Kitchens and Patricia A. Thompson},
  journal={Journal of endotoxin research},
  volume={11 4},
LPS binding protein (LBP) and CD14 play key roles in promoting innate immunity to Gram-negative bacteria by transferring LPS to the signaling receptor complex, MD-2/Toll-like receptor 4 (TLR4). LBP and soluble CD14 (sCD14) can also inhibit responses to LPS by mechanisms that depend on their concentration and environment; during acute inflammation and infection, their concentrations increase in plasma and extravascular fluids. Whereas low concentrations of LBP enhance responses to LPS, high LBP… CONTINUE READING
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