Modulatory effects of rutin on the expression of cytochrome P450s and antioxidant enzymes in human hepatoma cells

@article{Karakurt2016ModulatoryEO,
  title={Modulatory effects of rutin on the expression of cytochrome P450s and antioxidant enzymes in human hepatoma cells},
  author={Seda Tukenmez Karakurt},
  journal={Acta Pharmaceutica},
  year={2016},
  volume={66},
  pages={491 - 502}
}
  • S. Karakurt
  • Published 1 December 2016
  • Biology, Medicine, Chemistry
  • Acta Pharmaceutica
Abstract Expression of a drug and xenobiotic metabolizing enzymes, cytochrome P450s (CYPs), and antioxidant enzymes can be modulated by various factors. The flavonoid rutin was investigated for its anti-carcinogen and protective effects as well as modulatory action on CYPs and phase II enzymes in human hepatocellular carcinoma cells. Rutin inhibited proliferation of HEPG2 cells in a dose-dependent manner with the IC50 value of 52.7 μmol L-1 and invasion of HEPG2 cells (21.6 %, p = 0.0018) and… 

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