Modulatory effects of hypercapnia on in vitro and in vivo pulmonary endothelial-neutrophil adhesive responses during inflammation.

@article{Liu2008ModulatoryEO,
  title={Modulatory effects of hypercapnia on in vitro and in vivo pulmonary endothelial-neutrophil adhesive responses during inflammation.},
  author={Yuliang Liu and Balu K. Chacko and Ana Ricksecker and Roman Shingarev and Eric J Andrews and Rakesh P Patel and John D. Jr. Lang},
  journal={Cytokine},
  year={2008},
  volume={44 1},
  pages={108-17}
}
Reducing tidal volume as a part of a protective ventilation strategy may result in hypercapnia. In this study, we focused on the influence of hypercapnia on endothelial-neutrophil responses in models of inflammatory-stimulated human pulmonary microvascular endothelial cells (HMVEC) and in an animal model of lipopolysaccharide (LPS)-induced acute lung injury. Neutrophil adhesion and adhesion molecules expression and nuclear factor-kappaB (NF-kappaB) were analyzed in TNF-alpha and LPS-treated… CONTINUE READING