Modulatory effects of dopamine D3/2 agonists on kappa opioid-induced antinociception and diuresis in the rat

@article{Cook2000ModulatoryEO,
  title={Modulatory effects of dopamine D3/2 agonists on kappa opioid-induced antinociception and diuresis in the rat},
  author={Charles D. Cook and Andrew C. Barrett and Chockeo Syvanthong and Mitchell J. Picker},
  journal={Psychopharmacology},
  year={2000},
  volume={152},
  pages={14-23}
}
Abstract. Rationale: The dopamine (DA) D3/2 agonist 7-OH-DPAT has been shown to attenuate the behavioral effects of the mu agonist morphine as well as the development of morphine tolerance. Objectives: To evaluate the effects of DA D3/2 agonists [7-OH-DPAT, (+)-PD128,907, quinelorane, (-)-quinpirole], a D1 agonist (SKF38393), a D1 antagonist [(+)-SCH23390], a DA antagonist (spiperone), and an indirect DA agonist (cocaine) on the antinociceptive effects of kappa agonists (spiradoline, U69,593… Expand
Modulation of the discriminative stimulus effects of mu opioid agonists in rats: II. Effects of dopamine D2/3 agonists
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The results extend previous findings, which demonstrated that activation of D2/3 receptors attenuates the antinociceptive effects of mu agonists, to now include their discriminative stimulus effects as well. Expand
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Modulation of D2/3 receptors can, in turn, alter the locomotor-activating effects of morphine, according to the results of this study. Expand
The dopamine D3/2 agonist 7-OH-DPAT attenuates the development of morphine tolerance but not physical dependence in rats
TLDR
The D3/2 agonist 7-OH-DPAT can attenuate the antinociceptive effects of morphine in both acute and chronic preparations as well as the development of morphine tolerance and physical dependence in the rat. Expand
Modulation of the locomotor activating effects of the noncompetitive NMDA receptor antagonist MK801 by dopamine D2/3 receptor agonists in mice
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It is demonstrated that the DA system, through D2/3 receptor activation, modulates the locomotor activating effects produced by noncompetitive NMDA receptor blockade. Expand
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The proof-of-concept data from the rodent animal model suggest that, with age, block of D1R function may be considered as an alternative to the use of morphine, to modulate the response to painful stimuli. Expand
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The data suggest that the D3 receptor modulates the MOR system in the spinal cord, and that a dysfunction of the D 3 receptor can induce a morphine-resistant state, and is proposed to serve as a model to study the onset of morphine resistance at the spinal cords level. Expand
Kappa Opioid Agonist-Induced Diuresis: Characteristics, Mechanisms, and Beyond.
  • S. Inan
  • Medicine
  • Handbook of experimental pharmacology
  • 2021
TLDR
Characteristics, possible mechanisms, as well as therapeutic potentials of KOR agonist-induced diuresis are reviewed. Expand
Sex and rat strain determine sensitivity to κ opioid-induced antinociception
Abstract.Rationale: Recent studies indicate that sex and rodent strain are determinants of sensitivity to opioid-induced antinociception. Objectives: The present study examined the influence of sexExpand
A review of the properties of spiradoline: a potent and selective kappa-opioid receptor agonist.
TLDR
Although Spiradoline had promising effects in animal tests of analgesia, and a reasonably good safety profile in preliminary studies, it did not replace morphine as an analgesic and future development of spiradoline-like analgesic compounds should preferably focus on reduction of unwanted effects on the central nervous system. Expand
Dopamine D1 or D3 receptor modulators prevent morphine tolerance and reduce opioid withdrawal symptoms
TLDR
The data suggests that adjunct therapy with dopamine D1 or D3 receptor preferring modulators prevents morphine tolerance and reduces the duration of morphine withdrawal symptoms, and thus this combination has potential for long-term pain management therapy. Expand
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References

SHOWING 1-10 OF 56 REFERENCES
Selective attenuation of the antinociceptive effects of μ opioids by the putative dopamine D3 agonist 7-OH-DPAT
TLDR
The finding that 7-OH-DPAT markedly attenuated the effects of morphine and that these effects were reversed with spiperone suggests that activity at the D3, and possibly the D2, receptor can modulate μ agonist-induced antinociception. Expand
The dopamine D3/2 agonist 7-OH-DPAT attenuates the development of morphine tolerance but not physical dependence in rats
TLDR
The D3/2 agonist 7-OH-DPAT can attenuate the antinociceptive effects of morphine in both acute and chronic preparations as well as the development of morphine tolerance and physical dependence in the rat. Expand
Dopaminergic activity and the discriminative stimulus effects of mu opioids in pigeons: importance of training dose and attenuation by the D3 agonist (±)-7-OH-DPAT
TLDR
It is indicated that direct and indirect DA agonists share similar stimulus effects with a low but not high training dose of butorphanol, and in the high-training dose group, activation of the D3 receptor by (±)-7-OH-DPAT results in the attenuation of the discriminative stimulus effects of mu opioids. Expand
Evidence for a role for dopamine D3 receptors in the effects of dopamine agonists on operant behaviour in rats.
TLDR
The results of this study are consistent with the view that D3 DA receptors may play an important role in mediating the behavioural effects of DA agonists and that these receptors have a presynaptic location. Expand
Functional correlates of dopamine D3 receptor activation in the rat in vivo and their modulation by the selective antagonist, (+)-S 14297: II. Both D2 and "silent" D3 autoreceptors control synthesis and release in mesolimbic, mesocortical and nigrostriatal pathways.
TLDR
The data suggest that D3 (auto)receptors control synthesis and release of DA in dopaminergic pathways innervating the limbic system, cortex and striatum and that D2/D3 receptor antagonist haloperidol modified DA turnover upon administration alone. Expand
Discriminative stimulus properties of the putative dopamine D3 receptor agonist, (+)-PD 128907: role of presynaptic dopamine D2 autoreceptors
TLDR
It is suggested that presynaptic D2 receptors mediate the discriminative stimulus properties of (+)-PD 128907 and highlight the lack of selectivity of (+-PD 12 8907 for D3 receptors in vivo. Expand
Differential antagonism of U69,593- and bremazocine-induced antinociception by (-)-UPHIT: evidence of kappa opioid receptor multiplicity in mice.
TLDR
Pretreatment with (-)-UPHIT is a selective, long-lasting kappa antagonist which can differentially antagonize the antinociception produced by these two kappa agonists, suggesting actions of these agonists at kappa receptors. Expand
Dopamine D3 receptor agonists produce similar decreases in body temperature and locomotor activity in D3 knock-out and wild-type mice
TLDR
Results show that the presence of DA D3 receptors is not necessary for the expression of these effects induced by the three agonists or the antagonist supposedly selective for the D3 receptor subtype, and raises the question of the involvement of the D2-like family member in these behavioural effects and the issue of the in vivo selectivity of these four compounds. Expand
Kappa agonist-induced reduction in dopamine release: site of action and tolerance.
Kappa opioid agonists are known to inhibit dopamine release. We sought to determine the site of this action and the relationship of tolerance to this effect. Microdialysis perfusion of the nucleusExpand
Investigations into the nature of a 7-OH-DPAT discriminative cue: comparison with D-amphetamine.
TLDR
The failure of these drugs to generalise to amphetamine, suggest that there is little involvement of the dopamine D3 receptor subtype in mediating its discriminative stimulus properties. Expand
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