Modulatory effects of caffeine on methotrexate-induced cytogenotoxicity in mouse bone marrow.

@article{Choudhury2004ModulatoryEO,
  title={Modulatory effects of caffeine on methotrexate-induced cytogenotoxicity in mouse bone marrow.},
  author={R. C. Choudhury and A. K. Palo},
  journal={Environmental toxicology and pharmacology},
  year={2004},
  volume={15 2-3},
  pages={
          79-85
        }
}
Caffeine (CAF), a widely used and extensively studied chemical, is known for the reports on its controversial and inconsistent genotoxic effects, potentiative and protective effects from the genotoxicity of chemical and physical mutagens, and its modulatory effects on the action of antineoplastic drugs. Methotrexate (MTX), an antifolate antimetabolite, is a widely prescribed antineoplastic drug with significant clastogenic effects. In the present study, in addition to the assessment of… Expand
Modulation of methotrexate-induced cytogenotoxicity in mouse spermatogonia and its transmission in the male germline by caffeine.
TLDR
Modulation of the said three different pre-treated doses of CAF on MTX 10mg/kg-induced cytogenotoxic effects indicated that CAF pre-treatment was decreasing the MTX-induced clastogenicity in spermatogonia, and was lowering the concurrent transmission of such effects in the male germline of mice, significantly. Expand
Protecting effect of caffeine against vinblastine (an anticancer drug) induced genotoxicity in mice
TLDR
It is shown that caffeine exerts protective effect against vinblastin induced cytogenotoxicity and mitotic index in bone marrow cells, and further studies on molecular mechanism are interesting to develop it as an effective drug in cancer chemotherapy. Expand
Methotrexate-induced cytotoxicity and genotoxicity in germ cells of mice: intervention of folic and folinic acid.
TLDR
FA and FNA are reported to ameliorate the germ cell toxicity of MTX in mice as evident from the decreased sperm head abnormalities, seminiferous tubule damage, sperm DNA damage, TUNEL positive cells and increased sperm counts. Expand
Cytotoxic and genotoxic effects of methotrexate in germ cells of male Swiss mice.
TLDR
It can be concluded that MTX induced germ cell toxicity in mice and induced the testicular toxicity as evident from the histology of testis. Expand
Genotoxic Effect of Methotrexate on Bone Marrow Chromosomes and DNA of Male Albino Mice (Mus musculus)
TLDR
It can be concluded that methotrexate induced genetic damage on the chromosomes and DNA content of male albino mice even after single treatment with low doses. Expand
Protective role of taurine against genotoxic damage in mice treated with methotrexate and tamoxfine.
TLDR
It appears that taurine protects against anti-neoplastic drugs-induced genotoxicity in somatic and germ tissues and may be of therapeutic potential in alleviating the risk of secondary tumors in chemotherapy. Expand
Screening of cytoprotectors against methotrexate-induced cytogenotoxicity from bioactive phytochemicals
TLDR
The results indicated that bioactive phytochemicals combinations had the potential to be used as new cytoprotectors to reduce the risk of second cancers caused by methotrexate. Expand
Effects of Viscum album L. extract and quercetin on methotrexate-induced cyto-genotoxicity in mouse bone-marrow cells.
TLDR
It is suggested that VAE and QE may play a role in reducing cyto-genotoxicity induced by anti-neoplastic drugs during cancer chemotherapy. Expand
Protective Effects of Thymoquinone against Methotrexate-Induced Germ Cell Apoptosis in Male Mice
TLDR
TQ protects testicular germ cell against MTX-induced apoptosis by affecting related genes regulation and showing that different concentrations of TQ could improve the harmful effects caused by the MTX. Expand
Astaxanthin prevents the methotrexate-induced reproductive toxicity by targeting oxidative stress in male mice
TLDR
It is suggested that MTX seems to impair the male fertility through oxidative damage in one hand, and AST pretreatment might improve themale fertility by preventing oxidative stress-induced fertility disorders, on the other hand, while ASTpretreatment might also protect germ cells against MTX-induced oxidative stress. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 46 REFERENCES
Cytogenetic toxicity of methotrexate in mouse bone marrow.
TLDR
MTX was found more clastogenic in male mice than the females and the intermediate dose tested (10 mg/kg) was found to be more effective than the other doses and none of the doses of MTX inhibited cell proliferation during the first post-treated cell cycle. Expand
Potential genotoxic, mutagenic and antimutagenic effects of coffee: a review.
TLDR
The mutagenic potential of coffee and caffeine has been demonstrated in lower organisms, but usually at doses several orders of magnitude greater than the estimated lethal dose for caffeine in humans. Expand
Potentiation by caffeine of the frequencies of micronuclei induced by mitomycin C and cyclophosphamide in young mice.
TLDR
The pregnancy had no effect on MMC- or CP-induced clastogenicity although a tendency to a decreased sensitivity to the damaging activity of MMC seemed to be detected in pregnant C57Bl mice compared to virgin female animals. Expand
Effects of caffeine-induced defective DNA replication on SCE and chromosome aberrations produced by alkylating agents.
TLDR
The results do not support the concept that the process of SCE is a manifestation of CAF-sensitive post-replication repair of DNA damage (single-strand exchanges), but, instead, point to exchanges between the double-strands of the DNA duplex present in each chromatid. Expand
Caffeine Enhancement of the Effect of Anticancer Agents on Human Sarcoma Cells
TLDR
It is suggested that caffeine may be useful in enhancing the tumoricidal effect of anticancer drugs, especially DNA‐damaging agents, and possibly may aid in overcoming natural drug resistance. Expand
In vitro studies on genotoxicity and cytotoxicity of the anticancer drugs cisplatin and cofplaton, a caffeine-8-ether plus cisplatinum compound.
TLDR
First results from animal studies indicate that cofplaton exerts antitumor activity comparable to CDDP, and because of its relatively low genotoxicity it seems to be a promising drug in human anticancer therapy. Expand
The effect of caffeine in the in vivo SCE and micronucleus mutagenicity tests.
TLDR
It can be concluded that caffeine causes DNA damage only at dose levels in the LD50 range which is higher for hamsters than for mice, and in the SCE test with Chinese hamster 300 mg of caffeine were necessary to obtain a mutagenic effect. Expand
Effects of Methylxanthine Derivatives on Adriamycin Concentration and Antitumor Activity
TLDR
The metabolism of caffeine may weaken its effect as a biochemical modulator, and that pentoxifylline and theobromine would be of value as biochemical modulators of adriamycin. Expand
Caffeine does not cause override of the G2/M block induced by UVc or gamma radiation in normal human skin fibroblasts
TLDR
The data demonstrate that caffeine primarily inhibits replicative DNA synthesis and suggest that, at least in normal cells, caffeine potentiates the cytotoxicity of radiation by intervening in DNA repair rather than by overriding the G2/M block. Expand
Inducible protective processes in animal systems VI. Cross-adaptation and the influence of caffeine on the adaptive response in bone marrow cells of mouse.
TLDR
An example of cross-adaptation induced by CAF in EMS-treated in vivo mouse bone marrow cells and the results demonstrate an influence of CAF on the adaptive response. Expand
...
1
2
3
4
5
...