Corpus ID: 2698320

Modulatory effects of alpha-linolenic acid on generation of reactive oxygen species in elaidic acid enriched peritoneal macrophages in rats.

@article{Rao2014ModulatoryEO,
  title={Modulatory effects of alpha-linolenic acid on generation of reactive oxygen species in elaidic acid enriched peritoneal macrophages in rats.},
  author={Y. P. C. Rao and B. Lokesh},
  journal={Indian journal of experimental biology},
  year={2014},
  volume={52 9},
  pages={
          860-9
        }
}
  • Y. P. C. Rao, B. Lokesh
  • Published 2014
  • Chemistry, Medicine
  • Indian journal of experimental biology
  • Fatty acids are known to influence the ability of macrophages to generate reactive oxygen species (ROS). However the effect of elaidic acid (EA, 18:1 trans fatty acid) on ROS generation is not well studied. Rat peritoneal macrophages were enriched with elaidic acid by incubating the cells with 80 1M EA. The macrophages containing EA generated higher amounts of superoxide anion (O2*-), hydrogen peroxide (H2O2) and nitric oxide (NO) by 54, 123 and 237%, respectively as compared to control cells… CONTINUE READING
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