Modulatory effect of two novel CGRP receptor antagonists on nasal vasodilatatory responses to exogenous CGRP, capsaicin, bradykinin and histamine in anaesthetised pigs.

@article{Malis2001ModulatoryEO,
  title={Modulatory effect of two novel CGRP receptor antagonists on nasal vasodilatatory responses to exogenous CGRP, capsaicin, bradykinin and histamine in anaesthetised pigs.},
  author={Didier Malis and Beate Rist and Kevin Nicoucar and Annette G Beck-Sickinger and Denis R. Morel and J. S. Lacroix},
  journal={Regulatory peptides},
  year={2001},
  volume={101 1-3},
  pages={101-8}
}
Calcitonin gene-related peptide (CGRP) is a 37-amino acid peptide and potent vasodilatator agent located in sensory C fibres. Several functional studies suggest that CGRP could be involved in the vasodilatation of different vascular beds during neurogenic inflammation. We have studied, in pentobarbital anaesthetised pigs, the antagonistic effect of local… CONTINUE READING