Modulatory effect of plasminogen on NMDA-induced increase in intracellular free calcium concentration in rat cultured hippocampal neurons.

@article{Inoue1994ModulatoryEO,
  title={Modulatory effect of plasminogen on NMDA-induced increase in intracellular free calcium concentration in rat cultured hippocampal neurons.},
  author={Kazuhide Inoue and Shuichi Koizumi and Kazuyuki Nakajima and Makoto Hamanoue and Shinichi Kohsaka},
  journal={Neuroscience letters},
  year={1994},
  volume={179 1-2},
  pages={87-90}
}
The effect of plasminogen on the intracellular Ca2+ concentration ([Ca]i) was examined in cultured rat hippocampal neurons. Plasminogen (100 nM) did not increase [Ca]i in the presence of tetrodotoxin (TTX, 3 microM) but increased [Ca]i in the absence of TTX. In all the cells which responded to plasminogen (100 nM), NMDA (5 microM) also increased [Ca]i in the presence of TTX. Furthermore, plasminogen (100 nM) enhanced the NMDA-evoked [Ca]i increase, and the potentiation by plasminogen was… CONTINUE READING

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