Modulatory effect of glutathione status and antioxidants on methylmercury-induced free radical formation in primary cultures of cerebral astrocytes.

@article{Shanker2005ModulatoryEO,
  title={Modulatory effect of glutathione status and antioxidants on methylmercury-induced free radical formation in primary cultures of cerebral astrocytes.},
  author={Gouri Shanker and Tore Syversen and Judy L Aschner and Michael Aschner},
  journal={Brain research. Molecular brain research},
  year={2005},
  volume={137 1-2},
  pages={11-22}
}
Excessive free radical formation has been implicated as one of the causative factors in neurotoxic damage associated with variety of metals, including methylmercury (MeHg). Although the mechanism(s) associated with MeHg-dependent neurotoxicity remains far from clear, overwhelming data give credence to a mediatory role for astrocytes, a major cell type that preferentially accumulates MeHg. To extend our recent findings of MeHg-induced increase in ROS formation (G. Shanker, J.L. Aschner, T… CONTINUE READING
48 Citations
78 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 48 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 78 references

P

  • O. Sorg, B. Schilter
  • Honnegger, et al., Increased vulnerability of…
  • 2005

T

  • G. Shanker, J. L. Aschner
  • Syversen, et al., Free radical formation in…
  • 2004

C

  • G. J. Myers, P. W. Davidson
  • Cox, et al., Prenatal methylmercury exposure from…
  • 2003

Similar Papers

Loading similar papers…