Modulatory effect of estradiol and testosterone on the development of N-nitrosodiisopropanolamine induced thyroid tumors in female rats.

@article{Thiruvengadam2003ModulatoryEO,
  title={Modulatory effect of estradiol and testosterone on the development of N-nitrosodiisopropanolamine induced thyroid tumors in female rats.},
  author={A Thiruvengadam and Pera Govindarajulu and Michael Mariajoseph Aruldhas},
  journal={Endocrine research},
  year={2003},
  volume={29 1},
  pages={
          43-51
        }
}
Both experimental and clinical research support the conclusion that thyroid tumors are sex dependent. Also, several studies have pointed out that the use of oral contraceptives is associated with a higher risk of thyroid tumor. Most of the existing reports suggest indirect effects of sex steroids on thyroid tumor growth in women. In this work, we present data to support the direct promoting effect of estradiol and testosterone on carcinogen-induced thyroid tumorigenesis. Thyroid tumors were… CONTINUE READING