Modulatory activity of soluble beta amyloid on HPA axis function in rats.

@article{Morgese2014ModulatoryAO,
  title={Modulatory activity of soluble beta amyloid on HPA axis function in rats.},
  author={Maria Grazia Morgese and Paolo Tucci and Marilena Colaianna and Margherita Zotti and Vincenzo Cuomo and Stefania Schiavone and Luigia Trabace},
  journal={Current pharmaceutical design},
  year={2014},
  volume={20 15},
  pages={
          2539-46
        }
}
Despite the consolidation of the amyloid hypothesis, the main component of senile plaques in Alzheimer's disease (AD), recent findings have led to a conceptual shift opening new questions about the potential physiological role of this peptide. In addition, soluble beta amyloid (sBA), in transgenic AD model, resulted to be increased after chronic and acute stress and alterations in cortisol levels have been reported in AD. Impaired hypothalamic pituitary adrenal (HPA) axis has been linked to… CONTINUE READING

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