Modulatory action of metabotropic glutamate receptor (mGluR) 5 on mGluR1 function in striatal cholinergic interneurons

@article{Bonsi2005ModulatoryAO,
  title={Modulatory action of metabotropic glutamate receptor (mGluR) 5 on mGluR1 function in striatal cholinergic interneurons},
  author={Paola Bonsi and Dario Cuomo and C. De Persis and Diego Centonze and Giorgio Bernardi and Paolo Calabresi and Antonio Pisani},
  journal={Neuropharmacology},
  year={2005},
  volume={49},
  pages={104-113}
}
Within basal ganglia, group I metabotropic glutamate receptor subtypes (mGluR1 and 5) frequently co-localize in the same neuron. However, little is known about how these receptors functionally interact. We addressed this issue by means of electrophysiological recordings of striatal cholinergic interneurons, a neuronal subtype that co-express both group I mGluRs. The group I non-selective agonist 3,5-DHPG induced a membrane depolarization/inward current that was prevented by co-application of LY… Expand
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