Modulatory Mechanism of Polyphenols and Nrf2 Signaling Pathway in LPS Challenged Pregnancy Disorders

@article{Hussain2017ModulatoryMO,
  title={Modulatory Mechanism of Polyphenols and Nrf2 Signaling Pathway in LPS Challenged Pregnancy Disorders},
  author={Tarique Hussain and Bi'e Tan and Gang Liu and Ghulam Murtaza and Najma Rahu and Muhammad Waqar Saleem and Yulong Yin},
  journal={Oxidative Medicine and Cellular Longevity},
  year={2017},
  volume={2017}
}
Early embryonic loss and adverse birth outcomes are the major reproductive disorders that affect both human and animals. The LPS induces inflammation by interacting with robust cellular mechanism which was considered as a plethora of numerous reproductive disorders such as fetal resorption, preterm birth, teratogenicity, intrauterine growth restriction, abortion, neural tube defects, fetal demise, and skeletal development retardation. LPS-triggered overproduction of free radicals leads to… Expand
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The Role of Oxidative Stress and Antioxidant Balance in Pregnancy
TLDR
The role of oxidative stress in pregnancy-related diseases is highlighted and a balancing act between oxidant and antioxidant production is necessary at different stages of the pregnancy. Expand
“Molecular aspects of dietary polyphenols in pregnancy”
TLDR
This chapter provides an overview, based on the latest literature data, of the effects of dietary polyphenols on molecular mechanisms governing the various stages of pregnancy, as well as on vascular, endocrine, and neuronal factors. Expand
Enhanced Expression of miR-34a Enhances Escherichia coli Lipopolysaccharide-Mediated Endometritis by Targeting LGR4 to Activate the NF-κB Pathway
TLDR
It is observed that Gram-negative bacteria, represented by Escherichia coli, are the predominant pathogenic agents responsible for the recurrent occurrence of endometritis in dairy cows and miR-34a is regulated by IL-1β and suppresses the level of the LGR4 3′UTR, which in turn exacerbates the inflammatory response. Expand
Nrf2 Mediates the Anti-apoptotic and Anti-inflammatory Effects Induced by Gastrodin in Hydrogen Peroxide–Treated SH-SY5Y Cells
TLDR
GAS elicited anti-apoptotic and anti-inflammatory effects by a mechanism involving Nrf2 in SH-SY5Y cells and suppressed the GAS-induced cytoprotection. Expand
The attenuation of the toxic effects of LPS on mouse pre-implantation development by alpha-lipoic acid.
TLDR
The findings indicate that the reproductive toxicity of LPS could be overcome by ALA treatment, mainly due to the improvements made in intracellular antioxidant capacity as well as suppression of some inflammatory elements, especially the main receptor of TNF-α, the Tnf-RI/P-60, involved in induction of apoptosis. Expand
Regulation of Immune Function by Polyphenols
TLDR
In summary, polyphenols can be used to regulate intestinal mucosal immune responses, allergic diseases, and antitumour immunity. Expand
Prolonged Treatment with Centella asiatica Improves Memory, Reduces Amyloid-β Pathology, and Activates NRF2-Regulated Antioxidant Response Pathway in 5xFAD Mice.
TLDR
The results suggest that prolonged CAW exposure could be beneficial in Alzheimer's disease and that these effects likely involve NRF2 activation, and suggest that targetingNRF2 itself may be a relevant therapeutic strategy for improving synaptic plasticity and cognitive function in Alzheimer’s disease. Expand
In an in-vitro model using human fetal membranes, α-lipoic acid inhibits inflammation induced fetal membrane weakening.
TLDR
LA blocks TNF and thrombin induced FM weakening at two points, inhibiting both GM-CSF production and downstream action, suggesting that LA may be a potential standalone therapeutic agent, or supplement to current therapy for prevention of pPROM related spontaneous preterm birth, if preclinical studies to examine feasibility and safety during pregnancy are successfully accomplished. Expand
Astaxanthin reduces perfluorooctanoic acid cytotoxicity in Saccharomyces cerevisiae.
TLDR
The overall results suggest that PFA induces oxidative stress-mediated cytotoxicity in yeast cells, which were rescued by astaxanthin treatment, which suggest that the cells are protected from the PFA induced oxidative stress mediated cytot toxicity. Expand
Phytolacca dodecandra (Phytolaccaceae) Root Extract Exhibits Antioxidant and Hepatoprotective Activities in Mice with CCl4-Induced Acute Liver Damage
TLDR
The results suggest that the 80% methanol extract of P. dodecandra root can be used for the management of liver disease and was found to scavenge free radicals in vitro and inhibit lipid peroxidation in vivo. Expand
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