Modulatory Mechanism of Polyphenols and Nrf2 Signaling Pathway in LPS Challenged Pregnancy Disorders

@article{Hussain2017ModulatoryMO,
  title={Modulatory Mechanism of Polyphenols and Nrf2 Signaling Pathway in LPS Challenged Pregnancy Disorders},
  author={Tarique Hussain and Bi'e Tan and Gang Liu and Ghulam Murtaza and Najma Rahu and Muhammad Saleem and Yulong Yin},
  journal={Oxidative Medicine and Cellular Longevity},
  year={2017},
  volume={2017}
}
Early embryonic loss and adverse birth outcomes are the major reproductive disorders that affect both human and animals. The LPS induces inflammation by interacting with robust cellular mechanism which was considered as a plethora of numerous reproductive disorders such as fetal resorption, preterm birth, teratogenicity, intrauterine growth restriction, abortion, neural tube defects, fetal demise, and skeletal development retardation. LPS-triggered overproduction of free radicals leads to… 

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References

SHOWING 1-10 OF 156 REFERENCES
Curcumin inhibits placental inflammation to ameliorate LPS-induced adverse pregnancy outcomes in mice via upregulation of phosphorylated Akt
TLDR
Curcumin inhibited the expression of proinflammatory factors and macrophage infiltration in placenta and ameliorated LPS-induced adverse pregnancy outcomes in mice by inhibiting inflammation via upregulation of phosphorylated Akt.
The roles of cellular reactive oxygen species, oxidative stress and antioxidants in pregnancy outcomes.
Embryonic oxidative stress as a mechanism of teratogenesis with special emphasis on diabetic embryopathy.
  • A. Ornoy
  • Biology, Medicine
    Reproductive toxicology
  • 2007
The role of cytokines in mediating effects of prenatal infection on the fetus: implications for schizophrenia
TLDR
Data suggest that effects of maternal LPS exposure on the developing fetal brain are not mediated by the direct action of LPS, but via indirect actions at the level of the maternal circulation or placenta.
Evidence Implicating Peroxisome Proliferator-Activated Receptor-&ggr; in the Pathogenesis of Preeclampsia
TLDR
It is suggested that peroxisome proliferator-activated receptor-&ggr; may play a pivotal role in the progression of a healthy pregnancy and may critically regulate the risk of preeclampsia.
Zinc Supplementation during Pregnancy Protects against Lipopolysaccharide-Induced Fetal Growth Restriction and Demise through Its Anti-inflammatory Effect
TLDR
Zinc supplementation during pregnancy protects against LPS-induced fetal growth restriction and demise through its anti-inflammatory effect.
Modulation of Nrf2/ARE Pathway by Food Polyphenols: A Nutritional Neuroprotective Strategy for Cognitive and Neurodegenerative Disorders
TLDR
Low concentrations of epigallocatechin-3-gallate, the major green tea catechin, induces HO-1 by ARE/Nrf2 pathway in hippocampal neurons, and by this induction, it is able to protect neurons against different models of oxidative damages and identify a novel class of compounds that could be used for therapeutic purposes as preventive agents against cognitive decline.
Hydrogen Sulfide Delays LPS-Induced Preterm Birth in Mice via Anti-Inflammatory Pathways
TLDR
New in vivo evidence is provided for the roles of H2S in attenuating inflammation, and a potential novel therapeutic strategy for infection-related preterm labor is proposed.
...
...