Modulatory Mechanism of Polyphenols and Nrf2 Signaling Pathway in LPS Challenged Pregnancy Disorders
@article{Hussain2017ModulatoryMO, title={Modulatory Mechanism of Polyphenols and Nrf2 Signaling Pathway in LPS Challenged Pregnancy Disorders}, author={Tarique Hussain and Bi'e Tan and Gang Liu and Ghulam Murtaza and Najma Rahu and Muhammad Saleem and Yulong Yin}, journal={Oxidative Medicine and Cellular Longevity}, year={2017}, volume={2017} }
Early embryonic loss and adverse birth outcomes are the major reproductive disorders that affect both human and animals. The LPS induces inflammation by interacting with robust cellular mechanism which was considered as a plethora of numerous reproductive disorders such as fetal resorption, preterm birth, teratogenicity, intrauterine growth restriction, abortion, neural tube defects, fetal demise, and skeletal development retardation. LPS-triggered overproduction of free radicals leads to…
22 Citations
The Role of Oxidative Stress and Antioxidant Balance in Pregnancy
- BiologyMediators of inflammation
- 2021
The role of oxidative stress in pregnancy-related diseases is highlighted and a balancing act between oxidant and antioxidant production is necessary at different stages of the pregnancy.
Stretch Causes Cell Stress and the Downregulation of Nrf2 in Primary Amnion Cells
- Biology, MedicineBiomolecules
- 2022
The results showed that the modulation of the antioxidant response pathway in the fetal membranes through Nrf2 activation may be a viable approach to improve outcomes in pregnancy.
IL-1β mediates miR-34a promotes bovine endometritis via LGR4-NF-κB axis
- Biology
- 2021
It is confirmed that miR-34a is regulated by IL-1β and suppress the level of LGR4 3’UTR which in turn exacerbates the inflammatory response and might be a new indirection for treatment endometritis.
Enhanced Expression of miR-34a Enhances Escherichia coli Lipopolysaccharide-Mediated Endometritis by Targeting LGR4 to Activate the NF-κB Pathway
- BiologyOxidative medicine and cellular longevity
- 2021
It is observed that Gram-negative bacteria, represented by Escherichia coli, are the predominant pathogenic agents responsible for the recurrent occurrence of endometritis in dairy cows and miR-34a is regulated by IL-1β and suppresses the level of the LGR4 3′UTR, which in turn exacerbates the inflammatory response.
Nrf2 Mediates the Anti-apoptotic and Anti-inflammatory Effects Induced by Gastrodin in Hydrogen Peroxide–Treated SH-SY5Y Cells
- Biology, ChemistryJournal of Molecular Neuroscience
- 2019
GAS elicited anti-apoptotic and anti-inflammatory effects by a mechanism involving Nrf2 in SH-SY5Y cells and suppressed the GAS-induced cytoprotection.
The attenuation of the toxic effects of LPS on mouse pre-implantation development by alpha-lipoic acid.
- BiologyTheriogenology
- 2019
The role of nuclear factor erythroid 2–related factor 2 (NRF2) in normal and pathological pregnancy: A systematic review
- BiologyAmerican journal of reproductive immunology
- 2021
Evidence is synthesized on the role of Nrf2 in various adverse pregnancy outcomes (APOs) to reduce oxidative stress and inflammatory damage to the cell during pregnancy.
Regulation of Immune Function by Polyphenols
- Biology, MedicineJournal of immunology research
- 2018
In summary, polyphenols can be used to regulate intestinal mucosal immune responses, allergic diseases, and antitumour immunity.
Prolonged Treatment with Centella asiatica Improves Memory, Reduces Amyloid-β Pathology, and Activates NRF2-Regulated Antioxidant Response Pathway in 5xFAD Mice.
- BiologyJournal of Alzheimer's disease : JAD
- 2021
The results suggest that prolonged CAW exposure could be beneficial in Alzheimer's disease and that these effects likely involve NRF2 activation, and suggest that targetingNRF2 itself may be a relevant therapeutic strategy for improving synaptic plasticity and cognitive function in Alzheimer’s disease.
References
SHOWING 1-10 OF 156 REFERENCES
Curcumin inhibits placental inflammation to ameliorate LPS-induced adverse pregnancy outcomes in mice via upregulation of phosphorylated Akt
- Biology, MedicineInflammation Research
- 2016
Curcumin inhibited the expression of proinflammatory factors and macrophage infiltration in placenta and ameliorated LPS-induced adverse pregnancy outcomes in mice by inhibiting inflammation via upregulation of phosphorylated Akt.
The roles of cellular reactive oxygen species, oxidative stress and antioxidants in pregnancy outcomes.
- BiologyThe international journal of biochemistry & cell biology
- 2010
[125-POS]: Nrf2 deficiency interferes with trophoblast differentiation and affects the placental development in mice
- Medicine, Biology
- 2015
Embryonic oxidative stress as a mechanism of teratogenesis with special emphasis on diabetic embryopathy.
- Biology, MedicineReproductive toxicology
- 2007
Intrauterine exposure to flavonoids modifies antioxidant status at adulthood and decreases oxidative stress-induced DNA damage.
- BiologyFree radical biology & medicine
- 2013
The role of cytokines in mediating effects of prenatal infection on the fetus: implications for schizophrenia
- Medicine, BiologyMolecular Psychiatry
- 2006
Data suggest that effects of maternal LPS exposure on the developing fetal brain are not mediated by the direct action of LPS, but via indirect actions at the level of the maternal circulation or placenta.
Evidence Implicating Peroxisome Proliferator-Activated Receptor-&ggr; in the Pathogenesis of Preeclampsia
- Biology, MedicineHypertension
- 2011
It is suggested that peroxisome proliferator-activated receptor-&ggr; may play a pivotal role in the progression of a healthy pregnancy and may critically regulate the risk of preeclampsia.
Zinc Supplementation during Pregnancy Protects against Lipopolysaccharide-Induced Fetal Growth Restriction and Demise through Its Anti-inflammatory Effect
- Medicine, BiologyThe Journal of Immunology
- 2012
Zinc supplementation during pregnancy protects against LPS-induced fetal growth restriction and demise through its anti-inflammatory effect.
Modulation of Nrf2/ARE Pathway by Food Polyphenols: A Nutritional Neuroprotective Strategy for Cognitive and Neurodegenerative Disorders
- BiologyMolecular Neurobiology
- 2011
Low concentrations of epigallocatechin-3-gallate, the major green tea catechin, induces HO-1 by ARE/Nrf2 pathway in hippocampal neurons, and by this induction, it is able to protect neurons against different models of oxidative damages and identify a novel class of compounds that could be used for therapeutic purposes as preventive agents against cognitive decline.
Hydrogen Sulfide Delays LPS-Induced Preterm Birth in Mice via Anti-Inflammatory Pathways
- Medicine, BiologyPloS one
- 2016
New in vivo evidence is provided for the roles of H2S in attenuating inflammation, and a potential novel therapeutic strategy for infection-related preterm labor is proposed.