Modulatory Effects of l‐Carnitine on Glucocorticoid Receptor Activity

  title={Modulatory Effects of l‐Carnitine on Glucocorticoid Receptor Activity},
  author={Irini Manoli and MASSIMO U. Martino and Tomoshige Kino and Salvatore Alesci},
  journal={Annals of the New York Academy of Sciences},
Abstract: l‐Carnitine (3‐hydroxy‐4‐N,N,N‐trimethylaminobutyrate) is a conditionally essential nutrient with a major role in cellular energy metabolism. It is available in the United States as both a prescription drug and an over‐the‐counter nutritional supplement. Accumulating evidence from both animal and human studies indicates that pharmacologic doses of l‐carnitine (LCAR) have immunomodulatory effects resembling those of glucocorticoids (GC). On the other hand, in contrast to GC, which… 

Acetyl-L-carnitine and α-lipoic acid: possible neurotherapeutic agents for mood disorders?

L-carnitine and α-lipoic acid are pleiotropic agents capable of offering neuroprotective and possibly cognitive-enhancing effects for neuropsychiatric disorders in which cognitive deficits are an integral feature.

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Effect of L-carnitine and Hoodia gordonii Supplementation on Metabolic Markers and Physical Performance under Short Term Calorie Restriction in Rats

Evaluating the combined effect of H. gordonii and L-carnitine supplementation on metabolic changes and appetite regulatory peptides during calorie restriction concluded that approach could be practically suitable and effective in emergency situations of combat or food shortage.

Narrative Review: Glucocorticoids in Alcoholic Hepatitis—Benefits, Side Effects, and Mechanisms

  • Hong Lu
  • Medicine, Biology
    Journal of xenobiotics
  • 2022
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Protective Effect Of L-Carnitine Against Amiodarone-Induced Lung Toxicity In Rats

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Long-Term Effects of Neonatal Treatment With Dexamethasone, l-Carnitine, and Combinations Thereof in Rats

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l‐Carnitine Is a Modulator of the Glucocorticoid Receptor Alpha

It is concluded that pharmacologic doses of LC can activate GRα and, via this mechanism, regulate glucocorticoid‐responsive genes, potentially sharing some of the biological and therapeutic properties of glucocORTicoids.

Carnitine is a naturally occurring inhibitor of thyroid hormone nuclear uptake.

The data are consistent with carnitine being a peripheral antagonist of TH action, and they indicate a site of inhibition at or before the nuclear envelope.

Usefulness of L-carnitine, a naturally occurring peripheral antagonist of thyroid hormone action, in iatrogenic hyperthyroidism: a randomized, double-blind, placebo-controlled clinical trial.

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Effects of L-carnitine on serum triglyceride and cytokine levels in rat models of cachexia and septic shock.

It is concluded that carnitine has a therapeutic effect on morbidity and lipid metabolism in these disease models, and that these effects could be the result of down-regulation of cytokine production and/or increased clearance of cytokines.

Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells

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High dose L-carnitine improves immunologic and metabolic parameters in AIDS patients.

The data suggest that in vivo L-carnitine could prove useful in ameliorating both the immune response and lipid metabolism in patients with AIDS, irrespective of initial serum carnitines levels.

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Dialysis-related carnitine disorder and levocarnitine pharmacology.

  • A. Evans
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    American journal of kidney diseases : the official journal of the National Kidney Foundation
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Results indicate that anti-apoptotic actions of ALCAR and LC contribute to their neuroprotective effect.

The pursuit of differentiated ligands for the glucocorticoid receptor.

The methods for the evaluation of selective GR modulators are detailed and the evolution of new compounds where varying degrees of selectivity have been reported are described.