Corpus ID: 36060062

Modulatory Effect of Vitamin C on Genotoxic Effect of Endosulfan in Developing Albino Rats

@article{Manjula2006ModulatoryEO,
  title={Modulatory Effect of Vitamin C on Genotoxic Effect of Endosulfan in Developing Albino Rats},
  author={S. D. Manjula and Susan Benjamin and Kurady Laxminarayana Bairy},
  journal={Iranian Journal of Pharmacology and Therapeutics},
  year={2006},
  volume={5},
  pages={113-116}
}
The genotoxic effect of endosulfan and the modulatory effect of vitamin C in growing albino rats were studied by bone marrow micronucleus assay. Seven days old male Wistar rats were treated with 3, 6, 9, 12 mg/kg Endosulfan orally (10 pups/group), for up to 60 days, at intervals of 24h. For 2 more groups (n=10/group), Endosulfan 9 mg/kg and 12 mg/kg was administered along with vitamin C (20 mg/kg). One more group of rats were treated with cyclophosphamide as positive control. The genotoxic… Expand

Tables from this paper

Genotoxic Effect of Chlorpyrifos and Cypermethrin in Albino Rats
TLDR
The findings indicate that chlorpyrifos and cypermethrin, singly and especially in combination, could be mutagenic. Expand
Protective Effect of Vitamin E on Endosulfan Induced Testicular Toxicity in Swiss Mice (Mus musculus)
TLDR
It was observed that administration of vitamin E minimized the endosulfan induced damage and it can be concluded that pretreatment with vitamin E can alleviate the damage caused to testis by endOSulfan. Expand
Vitamin "C" as ameliorative agent Against thiodicarb toxicated Male albino rats(rattus norvegicus)
Thiodicarb is a carbamate insecticide has been used for several years in agriculture. The objective of this study was to investigate the possible protection of vitamin C (10 mg/kg body weight) asExpand
Pulmonary and genotoxicity of Bisphenol-A in Wistar albino rats
Bisphenol A (BPA) is one of the common environmental endocrine disruptors with estrogenic properties and is the building block of carbonate plastic and a component of resin coatings. Wide spread useExpand
Ameliorating effect of N-acetylcysteine and curcumin on pesticide-induced oxidative DNA damage in human peripheral blood mononuclear cells
TLDR
Results indicate that pesticide-induced oxidative stress is probably responsible for the DNA damage, and N-acetylcysteine or curcumin attenuate this effect by counteracting the oxidative stress. Expand
Toxicological evaluation of pH-sensitive nanoparticles of curcumin: acute, sub-acute and genotoxicity studies.
TLDR
The developed curcumin loaded polymeric nanoparticles of Eudragit S100 were found to be safe for oral administration for a short as well as a prolonged duration and genotoxicity studies proved the cellular safety of the developed formulation at the therapeutic dose, and even at doses equivalent to thrice the therapeutic doses. Expand
Nanotoxicology: evaluating toxicity potential of drug-nanoparticles
TLDR
This chapter has been drafted to describe some of the currently available techniques which may be industrially adopted for assessing the toxicological potential of drug loaded nanoparticles, including reproductive toxicity and genotoxicity assays. Expand
Draft toxicological profile for endosulfan
TLDR
The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects information for these toxic substances described therein, and begins with a public health statement that describes a substance's relevant toxicological properties. Expand

References

SHOWING 1-10 OF 26 REFERENCES
Biochemical studies on endosulfan toxicity in different age groups of rats.
TLDR
The studies indicated that the toxic effects of endosulfan are age-dependent, and erythrocyte (Na+, K+)-ATPase was maximally inhibited in 15-day-old rats. Expand
In vivo anticlastogenic effects of L-ascorbic acid in mice.
TLDR
AsA was found to be effective in reducing MN frequency induced by CP and BLM, and with MMC only, the highest dose showed a slight inhibitory effect. Expand
Antimutagenic efficacy of higher doses of vitamin C.
Vitamin C, when administered concurrently with a pesticide (endosulfan, phosphamidon or mancozeb), could significantly decrease the frequency of pesticide-induced clastogenic and mitosis-disruptiveExpand
Inhibition of cyclophosphamide and mitomycin C-induced sister chromatid exchanges in mice by vitamin C.
TLDR
The results indicate that ascorbic acid acts as an anti-SCE agent in both in vivo and in vivo/in vitro conditions in mice. Expand
Vitamin C mediated amelioration of pesticide genotoxicity in murine spermatocytes.
The effect of vitamin C on the genotoxicity of three pesticides (Endosulfan, Phosphamidon, Mancozeb) was monitored by screening meiotic (metaphase I) chromosomes in the primary spermatocytes of SwissExpand
Effects of various cyclophosphamide concentrations in vivo on sister chromatid exchanges (SCE) and chromosome aberrations of Chinese hamster bone marrow cells
TLDR
The in vivo SCE formation and the induction of chromosome aberrations in the bone marrow of Chinese hamsters were studied after various concentrations of cyclophosphamide, and the sensitivity of the two test methods was compared. Expand
Relationship between experimental results in mammals and man. I. Cytogenetic analysis of bone marrow injury induced by a single dose of cyclophosphamide.
TLDR
The presented results tend to a conclusion that micronucleus testing may be a very suitable method used for screening purpose, however, the method of classical cytogenetic analysis, especially the evaluation of breaks, still remains the most exact and reliable technique. Expand
Bioaccumulative potential and toxicity of endosulfan insecticide to non-target animals.
  • S. M. Naqvi, C. Vaishnavi
  • Biology, Medicine
  • Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology
  • 1993
1. Endosulfan insecticide is a polychlorinated compound used for controlling a variety of insects; it is practically water-insoluble, but readily adheres to clay particles and persists in soil andExpand
The genotoxicity of Hinosan, an organophosphorus pesticide in the in vivo mouse.
TLDR
The genotoxic potential of Edifenphos (Hinosan) was studied in the in vivo mouse system and Statistically significant chromosomal aberrations, micronucleus and sperm abnormalities revealed the genotoxicity of this compound. Expand
Studies on L-ascorbic acid metabolism in rats under chronic toxicity due to organophosphorus insecticides: effects of supplementation of L-ascorbic acid in high doses.
TLDR
Excess intake of vitamin C under the toxic conditions was found to be very effective in counteracting the growth retardation and also the alterations produced by parathion and malathion both at the enzymatic and histological levels. Expand
...
1
2
3
...