Corpus ID: 36060062

Modulatory Effect of Vitamin C on Genotoxic Effect of Endosulfan in Developing Albino Rats

  title={Modulatory Effect of Vitamin C on Genotoxic Effect of Endosulfan in Developing Albino Rats},
  author={S. D. Manjula and Susan Benjamin and Kurady Laxminarayana Bairy},
  journal={Iranian Journal of Pharmacology and Therapeutics},
The genotoxic effect of endosulfan and the modulatory effect of vitamin C in growing albino rats were studied by bone marrow micronucleus assay. Seven days old male Wistar rats were treated with 3, 6, 9, 12 mg/kg Endosulfan orally (10 pups/group), for up to 60 days, at intervals of 24h. For 2 more groups (n=10/group), Endosulfan 9 mg/kg and 12 mg/kg was administered along with vitamin C (20 mg/kg). One more group of rats were treated with cyclophosphamide as positive control. The genotoxic… Expand

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