Modulators of the vascular endothelin receptor in blood pressure regulation and hypertension.

@article{Khalil2011ModulatorsOT,
  title={Modulators of the vascular endothelin receptor in blood pressure regulation and hypertension.},
  author={Raouf A Khalil},
  journal={Current molecular pharmacology},
  year={2011},
  volume={4 3},
  pages={176-86}
}
Endothelin (ET) is one of the most investigated molecules in vascular biology. Since its discovery two decades ago, several ET isoforms, receptors, signaling pathways, agonists and antagonists have been identified. ET functions as a potent endothelium-derived vasoconstrictor, but could also play a role in vascular relaxation. In endothelial cells, preproET and big ET are cleaved by ET converting enzymes into ET-1, -2, -3 and -4. These ET isoforms bind with different affinities to ET(A) and ET(B… CONTINUE READING

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