Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function.

@article{Nahoum2007ModulatorsOT,
  title={Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function.},
  author={Virginie Nahoum and E. P{\'e}rez and Pierre Germain and F{\'a}tima Rodr{\'i}guez-Barrios and Fabio Manzo and Sabrina Kammerer and G{\'e}raldine Lemaire and Oliver Hirsch and Catherine A. Royer and Hinrich Gronemeyer and {\'A}ngel R de Lera and William Bourguet},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 44},
  pages={
          17323-8
        }
}
  • Virginie Nahoum, E. Pérez, +9 authors William Bourguet
  • Published in
    Proceedings of the National…
    2007
  • Biology, Medicine
  • Retinoid X receptors (RXRalpha, -beta, and -gamma) occupy a central position in the nuclear receptor superfamily, because they form heterodimers with many other family members and hence are involved in the control of a variety of (patho)physiologic processes. Selective RXR ligands, referred to as rexinoids, are already used or are being developed for cancer therapy and have promise for the treatment of metabolic diseases. However, important side effects remain associated with existing rexinoids… CONTINUE READING

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