Modulators of the Sphingosine 1-phosphate receptor 1.

  title={Modulators of the Sphingosine 1-phosphate receptor 1.},
  author={Mariangela Urbano and Miguel Guerrero and H. K. Rosen and Edward Roberts},
  journal={Bioorganic & medicinal chemistry letters},
  volume={23 23},
The Sphingosine 1-phosphate receptor (S1P-R) signaling system has proven to be of biological and medical importance in autoimmune settings. S1P1-R is a validated drug target for multiple sclerosis (MS) for which FTY720 (Fingolimod), a S1P1,3-5-R pan-agonist, was recently approved as the first orally active drug for the treatment of relapsing-remitting MS. Transient bradycardia and long half-life are the FTY720 critical pitfalls. This review provides the latest advances on next-generation S1P1-R… CONTINUE READING

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