Modulators of cyclic AMP metabolism induce syncytiotrophoblast formation in vitro.

@article{Wice1990ModulatorsOC,
  title={Modulators of cyclic AMP metabolism induce syncytiotrophoblast formation in vitro.},
  author={Burton M Wice and David N. Menton and Hans J. Geuze and Alan L. Schwartz},
  journal={Experimental cell research},
  year={1990},
  volume={186 2},
  pages={306-16}
}
During placental development cytotrophoblast stem cells fuse to form the syncytiotrophoblast, a multinucleate cytoplasm with a brush border in contact with the maternal blood. Biochemical differentiation including the expression of placental-specific proteins and hormones accompanies this maturation. However, the biochemical mechanisms responsible for these events are unknown. We have defined a system in which single cytotrophoblast-like cells of the human choriocarcinoma (BeWo) cell line… CONTINUE READING
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