Modulators of cigarette smoke-induced pulmonary emphysema in A/J mice.

  title={Modulators of cigarette smoke-induced pulmonary emphysema in A/J mice.},
  author={Thomas H. March and Julie A. Wilder and Dolores C Esparza and Patsy Y. Cossey and Lee F Blair and Lois K Herrera and Jacob D Mcdonald and M. Campen and Joe L. Mauderly and Jeanclare Seagrave},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  volume={92 2},
Mice develop pulmonary emphysema after chronic exposure to cigarette smoke (CS). In this study, the influence of gender, exposure duration, and concentration of CS on emphysema, pulmonary function, inflammation, markers of toxicity, and matrix metalloproteinase (MMP) activity was examined in A/J mice. Mice were exposed to CS at either 100 or 250 mg total particulate material/m(3) (CS-100 or CS-250, respectively) for 10, 16, or 22 weeks. Evidence of emphysema was first seen in female mice after… CONTINUE READING


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