Modulation of whole body protein metabolism, during and after exercise, by variation of dietary protein.

@article{Bowtell1998ModulationOW,
  title={Modulation of whole body protein metabolism, during and after exercise, by variation of dietary protein.},
  author={Joanna L. Bowtell and Graham P. Leese and K. Smith and Peter Watt and A Nevill and Olav Rooyackers and Ajm Wagenmakers and Michael John Rennie},
  journal={Journal of applied physiology},
  year={1998},
  volume={85 5},
  pages={
          1744-52
        }
}
The aim of this study was to investigate dietary protein-induced changes in whole body leucine turnover and oxidation and in skeletal muscle branched chain 2-oxo acid dehydrogenase (BCOADH) activity, at rest and during exercise. Postabsorptive subjects received a primed constant infusion of L-[1-13C,15N]leucine for 6 h, after previous consumption of a high- (HP; 1.8 g . kg-1 . day-1, n = 8) or a low-protein diet (LP; 0.7 g . kg-1 . day-1, n = 8) for 7 days. The subjects were studied at rest for… 
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81 Citations
Highly Influential Citations
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Background Citations
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Methods Citations
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81 Citations

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Citation Type

Effect of oral glucose on leucine turnover in human subjects at rest and during exercise at two levels of dietary protein
TLDR
The sparing effect of glucose on leucine oxidation appears only to occur if previous protein intake was high, and was not mediated by a suppression of BCOADH fractional activity but may be due to reduced substrate availability.
Postexercise whole-body protein turnover response to three levels of protein intake.
TLDR
Findings from this study show that variations in protein intake can alter plasma amino acid levels and modulate rates of WBPTO after exercise.
Effect of glycogen availability on human skeletal muscle protein turnover during exercise and recovery.
TLDR
It is demonstrated, using contemporary stable isotope methodology, that CHO availability influences the rates of skeletal muscle and whole body protein synthesis, degradation, and net balance during prolonged exercise in humans.
Aerobic exercise training decreases leucine oxidation at rest in healthy adults.
TLDR
Improved protein utilization in response to exercise training in weight-stable subjects is indicated, emphasizing the importance of dietary control, with specific regard to energy and protein intakes, in the characterization of protein utilizationIn response to an exercise intervention.
Level of dietary protein impacts whole body protein turnover in trained males at rest.
Endurance Exercise Attenuates Postprandial Whole-Body Leucine Balance in Trained Men
TLDR
It is demonstrated that endurance exercise does not modulate dietary leucine availability from a mixed meal but attenuates postprandial whole-bodyLeucine balance in trained young men.
Combined ingestion of protein and carbohydrate improves protein balance during ultra-endurance exercise.
TLDR
It is concluded that, even during 6 h of exhaustive exercise in trained athletes using carbohydrate supplements, net protein oxidation does not increase compared with the resting state and/or postexercise recovery.
Endurance exercise training attenuates leucine oxidation and BCOAD activation during exercise in humans.
TLDR
It was found that 38 days of Endurance exercise training significantly attenuated both leucine oxidation and BCOAD activation during 90 min of endurance exercise at 60% VO(2 peak) for both ABS and REL exercise intensities.
Three weeks of caloric restriction alters protein metabolism in normal-weight, young men.
TLDR
3 wk of caloric restriction reduced leucine flux and R(ox) during exercise in normal-weight young men despite negative nitrogen balance and loss of lean mass, whole body exercise performance was well maintained in response to CR.
Dietary protein intake impacts human skeletal muscle protein fractional synthetic rates after endurance exercise.
TLDR
It is established that habitual dietary protein intake in humans modulates skeletal muscle protein synthesis after an endurance exercise bout, and future studies directed at mechanisms by which level of protein intake influences skeletal muscle turnover are needed.
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References

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