Modulation of visual cortical plasticity by acetylcholine and noradrenaline

  title={Modulation of visual cortical plasticity by acetylcholine and noradrenaline},
  author={M. Bear and W. Singer},
  • M. Bear, W. Singer
  • Published 1986
  • Biology, Medicine
  • Nature
  • During a critical period of postnatal development, the temporary closure of one eye in kittens will permanently shift the ocular dominance (OD) of neurones in the striate cortex to the eye that remains open1. The OD plasticity can be substantially reduced if the cortex is infused continuously with the catecholamine neurotoxin 6-hydroxydopamine (6-OHDA) during the period of monocular deprivation2–5, an effect that has been attributed to selective depletion of cortical noradrenaline6. However… CONTINUE READING
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