Modulation of vertebrate brain Na+ and K+ channels by subtypes of protein kinase C.

@article{Lotan1990ModulationOV,
  title={Modulation of vertebrate brain Na+ and K+ channels by subtypes of protein kinase C.},
  author={Ilana Lotan and Nathan Dascal and Zvi Naor and Rony Boton},
  journal={FEBS letters},
  year={1990},
  volume={267 1},
  pages={25-8}
}
Effects of purified subtypes I, II and III of protein kinase C (PKC) on voltage-dependent transient K+ (A) and Na+ channels were studied in Xenopus oocytes injected with chick brain RNA. The experiments were performed in the constant presence of 10 nM beta-phorbol 12-myristate-13-acetate (PMA). Intracellular injection of subtype I (tau) reduced the A-current (IA), with no effect on Na+ current (INa). PKC subtype II (beta 1 + beta 2) and III (alpha) reduced both currents. PKC did not affect the… CONTINUE READING

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