Modulation of vascular tonus by the endothelium in experimental diabetes.

@article{Wakabayashi1987ModulationOV,
  title={Modulation of vascular tonus by the endothelium in experimental diabetes.},
  author={Ichiro Wakabayashi and Katsuhiko Hatake and Naoto Kimura and Eizo Kakishita and Kaoru Nagai},
  journal={Life sciences},
  year={1987},
  volume={40 7},
  pages={
          643-8
        }
}
The role of the vascular endothelium in the contractile response of aortas from streptozotocin-induced diabetic rats was investigated using selected agents. Contractile response to KCl was not affected by removal of the endothelium in both diabetic and control groups, but was diminished in the diabetic rats compared to the control rats. Contractile response to clonidine markedly increased after removal of the endothelium in the control group, with the increment being less in the diabetic group… CONTINUE READING

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