Modulation of type-1 protein phosphatase by synthetic peptides corresponding to the carboxyl terminus.

@article{Martin1991ModulationOT,
  title={Modulation of type-1 protein phosphatase by synthetic peptides corresponding to the carboxyl terminus.},
  author={Bruce L. Martin and Carol Shriner and David L. Brautigan},
  journal={FEBS letters},
  year={1991},
  volume={285 1},
  pages={6-10}
}
Protein phosphatase type-1 (PP-1) has a protease resistant catalytic core Mr = 35,000 (PP-35K) and carboxyl terminal segment which affects activity with various substrates. We found that micromolar concentration of a synthetic peptide, corresponding to residues 312-326 of the PP-1 carboxyl terminus (P312-326) that is missing from PP-35K, increased the… CONTINUE READING