Modulation of tumor cell stiffness and migration by type IV collagen through direct activation of integrin signaling pathway.

@article{Chen2014ModulationOT,
  title={Modulation of tumor cell stiffness and migration by type IV collagen through direct activation of integrin signaling pathway.},
  author={Sheng-Yi Chen and Jo-Shi Lin and Bei-chang Yang},
  journal={Archives of biochemistry and biophysics},
  year={2014},
  volume={555-556},
  pages={1-8}
}
Excessive collagen deposition plays a critical role in tumor progression and metastasis. To understand how type IV collagen affects mechanical stiffness and migration, low-collagen-IV-expressing transfectants of B16F10, U118MG, and Huh7 (denoted shCol cells) were established by the lentiviral-mediated delivery of small interfering RNA against type IV-α1 collagen (Col4A1). Although having similar growth rates, shCol cells showed a flatter morphology compared to that of the corresponding controls… CONTINUE READING
Highly Cited
This paper has 24 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

Similar Papers

Loading similar papers…