Modulation of tumor cell gene expression and phenotype by the organspecific metastatic environment

Abstract

The mechanistic basis of a metastatic cell's ability to proliferate in the parenchyma of certain organs and develop organ-specific metastases is under intense investigation. Signals from paracrine or autocrine pathways, alone or in combination, may regulate tumor cell proliferation with the eventual outcome dependent on the net balance of stimulatory and… (More)
DOI: 10.1007/BF00690601

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