Modulation of transforming growth factor-beta secretion from malignant glioma cells by interleukin-1 beta.

@article{Naganuma1996ModulationOT,
  title={Modulation of transforming growth factor-beta secretion from malignant glioma cells by interleukin-1 beta.},
  author={Hirofumi Naganuma and Atsushi Sasaki and Eiji Satoh and Mitsuyasu Nagasaka and Shuji Nakano and Shiro Isoe and Hideaki Nukui},
  journal={Neurologia medico-chirurgica},
  year={1996},
  volume={36 3},
  pages={
          145-50
        }
}
Malignant glioma cells secrete transforming growth factor-beta (TGF-beta) which has potent immunosuppressive properties. We investigated the effect of interleukin-1 beta (IL-1 beta) on TGF-beta secretion from malignant glioma cells in vitro. T98G glioblastoma cells were treated with various doses of IL-1 beta and the TGF-beta activity in the supernatant was determined using a specific bioassay. Six other human malignant glioma cell lines were also treated with 1000 U/ml of IL-1 beta, and the… CONTINUE READING