Modulation of transforming growth factor-β signaling and extracellular matrix production in myxomatous mitral valves by angiotensin II receptor blockers.

@article{Geirsson2012ModulationOT,
  title={Modulation of transforming growth factor-β signaling and extracellular matrix production in myxomatous mitral valves by angiotensin II receptor blockers.},
  author={Arnar Geirsson and Mansher Singh and Rahmat Ali and Hussain Abbas and Wei Li and Juan Antonio S{\'a}nchez and Sabet Hashim and George Tellides},
  journal={Circulation},
  year={2012},
  volume={126 11 Suppl 1},
  pages={S189-97}
}
BACKGROUND Little is known about the pathophysiology of myxomatous degeneration of the mitral valve, the pathological hallmark of mitral valve prolapse, associated with symptomatic mitral regurgitation, heart failure, and death. Excess transforming growth factor (TGF)-β signaling is known to cause mitral valve degeneration and regurgitation in a mouse model of Marfan syndrome. We examined if TGF-β signaling is dysregulated in clinical specimens of sporadic mitral valve prolapse compared with… CONTINUE READING
30 Citations
26 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 26 references

Similar Papers

Loading similar papers…