Modulation of transcription by PARP-1: consequences in carcinogenesis and inflammation.

  title={Modulation of transcription by PARP-1: consequences in carcinogenesis and inflammation.},
  author={Roc{\'i}o Aguilar-Quesada and Jos{\'e} Antonio Mu{\~n}oz-G{\'a}mez and David Mart{\'i}n-Oliva and Andre{\'i}na Peralta-Leal and Rosa Quiles-P{\'e}rez and Jos{\'e} Manuel Rodr{\'i}guez-Vargas and M Ru{\'i}z de Almodovar and Claude Cond{\'e} and {\'A}ngela Ruiz-Extremera and Francisco Javier Oliver},
  journal={Current medicinal chemistry},
  volume={14 11},
Post-translational modification of proteins by poly(ADP-ribosyl)ation is involved in the regulation of a number of biological functions. While an 18 member superfamily of poly(ADP-ribose) polymerases (PARP)s has been described PARP-1 accounts for more than 90% of the poly(ADP-ribosyl)ating capacity of the cells. PARP-1 act as a DNA nick sensor and is activated by DNA breaks to cleave NAD(+) into nicotinamide and ADP-ribose to synthesize long branching poly(ADP-ribose) polymers (PAR) covalently… 

Immunomodulatory Roles of PARP-1 and PARP-2: Impact on PARP-Centered Cancer Therapies

It is now emerging that PARP-1 andPARP-2 may not only impact cancer cell biology, but also modulate the anti-tumor immune response, and may provide invaluable clues to the rational development of more selective PARp-centered therapies which target both the cancer and its microenvironment.

How to kill tumor cells with inhibitors of poly(ADP‐ribosyl)ation

A number of high‐potency PARP inhibitors have been developed during the last decade and are currently evaluated as cancer therapeutics in clinical trials by several leading pharmaceutical companies.

Poly(ADP-Ribose) Polymerase 1-Sirtuin 1 Functional Interplay Regulates LPS-Mediated High Mobility Group Box 1 Secretion

It is demonstrated in an in vitro model that LPS treatment leads to hyperacetylated HMGB1 with concomitant reduction in nuclear HDAC activity and that PARP1 physically interacts with SIRT1, a member of the Class III histone deacetylases, sirtuin-1.

Multitasking Roles for Poly(ADP-ribosyl)ation in Aging and Longevity

The mechanisms underlying the various roles of PARylation in longevity and aging are highlighted with a focus on molecular and cellular mechanisms.

The Multifactorial Role of PARP-1 in Tumor Microenvironment

Drawing conclusions arising from recent studies on the interaction between PARPs, PAR and key features of tumor microenvironment such as hypoxia, autophagy, tumor initiating cells, angiogenesis and cancer-associated immune response are summarized.

Pharmacological inhibition of poly(ADP-ribose) polymerase activity down-regulates the expression of syndecan-4 and Id-1 in endothelial cells.

Analysis of gene and protein expression indicated that a 2-h exposure of human endothelial cells to GPI 15427 induced a rapid decrease of syndecan-4, a transmembrane protein involved in modulation of cell signalling during angiogenesis that plays a role in endothelial cell migration and adhesion.

Inflammatory and age-related pathologies in mice with ectopic expression of human PARP-1




The functional role of poly(ADP-ribose)polymerase 1 as novel coactivator of NF-κB in inflammatory disorders

A more precise role for PARP-1 in NF-κB-dependent gene regulation and cellular metabolism during development of pathophysiological processes is discussed and might provide new insights into the pathophysiology of different diseases such as type I diabetes and septic shock.

Importance of poly(ADP-ribose) polymerases in the regulation of DNA-dependent processes.

Poly(ADP-ribosyl)ation of proteins is involved in the regulation of basal cellular processes and seems to be crucial for genomic integrity and cell survival and downregulates their activities.