Modulation of transcription by PARP-1: consequences in carcinogenesis and inflammation.

@article{AguilarQuesada2007ModulationOT,
  title={Modulation of transcription by PARP-1: consequences in carcinogenesis and inflammation.},
  author={Roc{\'i}o Aguilar-Quesada and Jos{\'e} Antonio Mu{\~n}oz-G{\'a}mez and David Mart{\'i}n-Oliva and Andre{\'i}na Peralta-Leal and Rosa Quiles-P{\'e}rez and Jos{\'e} Manuel Rodr{\'i}guez-Vargas and M Ru{\'i}z de Almodovar and Claude Cond{\'e} and {\'A}ngela Ruiz-Extremera and Francisco Javier Oliver},
  journal={Current medicinal chemistry},
  year={2007},
  volume={14 11},
  pages={
          1179-87
        }
}
Post-translational modification of proteins by poly(ADP-ribosyl)ation is involved in the regulation of a number of biological functions. While an 18 member superfamily of poly(ADP-ribose) polymerases (PARP)s has been described PARP-1 accounts for more than 90% of the poly(ADP-ribosyl)ating capacity of the cells. PARP-1 act as a DNA nick sensor and is activated by DNA breaks to cleave NAD(+) into nicotinamide and ADP-ribose to synthesize long branching poly(ADP-ribose) polymers (PAR) covalently… 

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