Modulation of tight junction proteins in the perineurium for regional pain control.

@article{Hackel2012ModulationOT,
  title={Modulation of tight junction proteins in the perineurium for regional pain control.},
  author={Dagmar Hackel and Alexander Brack and Michael Fromm and Heike L Rittner},
  journal={Annals of the New York Academy of Sciences},
  year={2012},
  volume={1257},
  pages={199-206}
}
Peripheral neurons are surrounded by the perineurium that forms the blood-nerve barrier and protects the nerve. Although the barrier serves as protection, it also hampers drug delivery of analgesic drugs to the peripheral nerve. We previously showed that opening of the barrier using hypertonic solutions facilitates drug delivery, for example, of hydrophilic opioids, which selectively target nociceptors. The perineurial barrier is formed by tight junction proteins, including claudin-1, claudin-5… CONTINUE READING

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