Modulation of thymocyte apoptosis by isoproterenol and prostaglandin E2.

  title={Modulation of thymocyte apoptosis by isoproterenol and prostaglandin E2.},
  author={Kazuhiro Suzuki and Takushi Tadakuma and Harutoshi Kizaki},
  journal={Cellular immunology},
  volume={134 1},
Isoproterenol and prostaglandin E2 increased cAMP levels in mouse thymocytes transiently, but failed to induce significant internucleosomal DNA fragmentation in thymocytes with a 24-hr incubation. However, these substances showed synergistic interaction with forskolin in the accumulation of cAMP and DNA fragmentation. The addition of 12-O-tetradecanoyl 13-acetate, an activator of protein kinase C, with isoproterenol or particularly with prostaglandin E2 enhanced DNA fragmentation. These results… CONTINUE READING
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