Modulation of thiol homeostasis induced by H2S-releasing aspirin.

  title={Modulation of thiol homeostasis induced by H2S-releasing aspirin.},
  author={Daniela Giustarini and Piero del Soldato and Anna Sparatore and Ranieri Rossi},
  journal={Free radical biology & medicine},
  volume={48 9},
The H(2)S-releasing aspirin (ACS14) containing a dithiolethione moiety has been demonstrated to maintain the thromboxane-suppressing activity of the parent compound, but it seems to spare the gastric mucosa by affecting redox imbalance through increased H(2)S/glutathione (GSH) formation. Nevertheless, the mechanisms by which ACS14 is able to elevate the levels of these agents has not been fully elucidated so far. In this manuscript the effect of an acute ip administration of ACS14 and of its… CONTINUE READING

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