Modulation of the unfolded protein response is the core of microRNA-122-involved sensitivity to chemotherapy in hepatocellular carcinoma.

@article{Yang2011ModulationOT,
  title={Modulation of the unfolded protein response is the core of microRNA-122-involved sensitivity to chemotherapy in hepatocellular carcinoma.},
  author={Fu Yang and Ling Zhang and Fang Wang and Yue Yun Wang and Xi-song Huo and Yi-xuan Yin and Yu-qi Wang and Lin Zhang and Shu-Han Sun},
  journal={Neoplasia},
  year={2011},
  volume={13 7},
  pages={590-600}
}
The loss of microRNA-122 (miR-122) expression correlates to many characteristic properties of hepatocellular carcinoma (HCC) cells, including clonogenic survival, anchorage-independent growth, migration, invasion, epithelial-mesenchymal transition, and tumorigenesis. However, all of these findings do not sufficiently explain the oncogenic potential of miR-122. In the current study, we used two-dimensional differential in-gel electrophoresis to measure changes in the expression of thousands of… CONTINUE READING