Modulation of the tumor vasculature functionality by ionizing radiation accounts for tumor radiosensitization and promotes gene delivery

@article{Sonveaux2002ModulationOT,
  title={Modulation of the tumor vasculature functionality by ionizing radiation accounts for tumor radiosensitization and promotes gene delivery},
  author={Pierre Sonveaux and Chantal Dessy and Agnès Brouet and B{\'e}n{\'e}dicte F. Jordan and Vincent Gr{\'e}goire and Bernard Gallez and Jean-Luc Balligand and Olivier Feron},
  journal={The FASEB Journal},
  year={2002},
  volume={16}
}
The ultimate goal of radiotherapy is to induce irreversible damages in genetically unstable, fast‐growing cancer cells while minimizing the cytotoxic effects on host tissues. The satus of the tumor vasculature is particular because it is located within the tumor but mostly arises from host cells. The aim of this study was to characterize the effects of low‐dose irradiation on the function of endothelial cells lining tumor vessels. Using isolated arterioles mounted on a pressure myograph, we… 
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  • P. Sonveaux
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Targeting Tumor Perfusion and Oxygenation to Improve the Outcome of Anticancer Therapy1
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This review summarizes the current knowledge about the development and use of tumor-selective vasodilators, inhibitors of tumor cell respiration, and drugs and treatments combining both activities in the context of tumor sensitization to X-ray radiotherapy and compares them in terms of sensitivity, quantitative or semi-quantitative properties, temporal, and spatial resolutions.
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  • Medicine, Biology
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • 2013
Manipulation of tumor oxygenation and radiosensitivity through modification of cell respiration. A critical review of approaches and imaging biomarkers for therapeutic guidance.
Endothelin-1 is a critical mediator of myogenic tone in tumor arterioles: implications for cancer treatment.
TLDR
Blocking the tumor-selective increase in the vascular endothelin-1/ETA pathway led to unravel an important reserve of vasorelaxation that can be exploited to selectively increase tumor response to radiotherapy.
Arterioles : Implications for Cancer Treatment Endothelin-1 Is a Critical Mediator of Myogenic Tone in Tumor
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Blocking the tumor-selective increase in the vascular endothelin-1/ ETA pathway led to unravel an important reserve of vasorelaxation that can be exploited to selectively increase tumor response to radiotherapy.
Botulinum toxin potentiates cancer radiotherapy and chemotherapy.
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The opening of the vascular bed induced by BoNT-A offers a way to significantly increase the response of tumors to radiotherapy and chemotherapy and is shown to inhibit neurogenic tone in the tumor vasculature.
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