Modulation of the tumor microenvironment and inhibition of EGF/EGFR pathway: novel anti-tumor mechanisms of Cannabidiol in breast cancer.

@article{Elbaz2015ModulationOT,
  title={Modulation of the tumor microenvironment and inhibition of EGF/EGFR pathway: novel anti-tumor mechanisms of Cannabidiol in breast cancer.},
  author={Mohamad Elbaz and Mohd Wasim Nasser and Janani Ravi and Nissar Ahmad Wani and Dinesh K. Ahirwar and Helong Zhao and Steve Oghumu and Abhay R Satoskar and Konstantin Shilo and William E Carson and Ramesh Kumar Ganju},
  journal={Molecular oncology},
  year={2015},
  volume={9 4},
  pages={906-19}
}
The anti-tumor role and mechanisms of Cannabidiol (CBD), a non-psychotropic cannabinoid compound, are not well studied especially in triple-negative breast cancer (TNBC). In the present study, we analyzed CBD's anti-tumorigenic activity against highly aggressive breast cancer cell lines including TNBC subtype. We show here -for the first time-that CBD significantly inhibits epidermal growth factor (EGF)-induced proliferation and chemotaxis of breast cancer cells. Further studies revealed that… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 32 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 61 references

Supplementary data Supplementary data related to this article can be found online at http://dx.doi.org/10.1016/j.molonc.2014.12.010

  • A. Appendix
  • 2014

Cannabinoids can be classified into phyto-cannabinoids

  • Yu
  • 2013

Similar Papers

Loading similar papers…