Modulation of the tumor cell death pathway by androgen receptor in response to cytotoxic stimuli.

@article{Frezza2011ModulationOT,
  title={Modulation of the tumor cell death pathway by androgen receptor in response to cytotoxic stimuli.},
  author={Michael Joseph Frezza and Huanjie Yang and Q Ping Dou},
  journal={Journal of cellular physiology},
  year={2011},
  volume={226 11},
  pages={
          2731-9
        }
}
Despite an initial response from androgen deprivation therapy, most prostate cancer patients relapse to a hormone-refractory state where tumors still remain dependent on androgen receptor (AR) function. We have previously shown that AR breakdown correlates with the induction of cancer cell apoptosis by proteasome inhibition. However, the involvement of AR in modulating the cell death pathway has remained elusive. To investigate this, we used an experimental model consisting of parental PC-3… CONTINUE READING
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