Modulation of the triggering receptor expressed on myeloid cells-1 pathway during pneumonia in rats.

@article{Gibot2006ModulationOT,
  title={Modulation of the triggering receptor expressed on myeloid cells-1 pathway during pneumonia in rats.},
  author={S{\'e}bastien Gibot and Corentine Alauzet and Fr{\'e}d{\'e}ric Massin and Nassira Sennoune and Gilbert Charles Faure and M V B{\'e}n{\'e} and Alain Lozniewski and P. E. Bollaert and Bruno L{\'e}vy},
  journal={The Journal of infectious diseases},
  year={2006},
  volume={194 7},
  pages={975-83}
}
BACKGROUND Triggering receptor expressed on myeloid cells-1 (TREM-1) is a cell-surface molecule that has been identified on both human and murine polymorphonuclear neutrophils and mature monocytes. The activation of TREM-1 in the presence of microbial components amplifies the inflammatory response and may be responsible for the hyperresponsiveness observed during the initial stage of sepsis. The aim of the present study was to investigate the effect of the modulation of the TREM-1 pathway… CONTINUE READING

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