Modulation of the transactivation function and stability of Krüppel-like zinc finger protein Gli-similar 3 (Glis3) by Suppressor of Fused.

@article{Zeruth2011ModulationOT,
  title={Modulation of the transactivation function and stability of Kr{\"u}ppel-like zinc finger protein Gli-similar 3 (Glis3) by Suppressor of Fused.},
  author={Gary T Zeruth and Xiao-Ping Yang and Anton M Jetten},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 25},
  pages={22077-89}
}
Glis3 is a member of the Glis subfamily of Krüppel-like zinc finger transcription factors. Recently, Glis3 has been linked to both type I and type II diabetes and shown to positively regulate insulin gene expression. In this study, we have identified a region within the N terminus of Glis3 that shares high levels of homology with the Cubitus interruptus (Ci)/Gli family of proteins. We demonstrated that Glis3 interacts with Suppressor of Fused (SUFU), which involves a VYGHF motif located within… CONTINUE READING