Modulation of the stimulus effects of (+)amphetamine by the 5-HT6 antagonist MS-245

  title={Modulation of the stimulus effects of (+)amphetamine by the 5-HT6 antagonist MS-245},
  author={Manik Reddy Pullagurla and Tatiana S Bondareva and Richard Young and Richard A Glennon},
  journal={Pharmacology Biochemistry and Behavior},

Effects of serotonin (5-HT)6 receptor ligands on responding for cocaine reward and seeking in rats.

Study into a possible mechanism responsible for the antidepressant-like activity of the selective 5-HT6 receptor antagonist SB-399885 in rats.

The results described in the present paper indicate that the anti-immobility activity of SB-399885 is not connected with 5-HT innervation, and that D(1)- and D(2-like receptors and alpha(2)-adrenoceptors are involved in this action.

An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function

  • K. Fone
  • Biology, Psychology
  • 2008

Impact of regional 5-HT depletion on the cognitive enhancing effects of a typical 5-ht6 receptor antagonist, Ro 04-6790, in the Novel Object Discrimination task

The ability of Ro 04-6790 to prolong object recognition memory requires blockade of MR 5-HT function, and widespread LV or selective MR, but not DR lesions, abolished the ability to delay natural forgetting.

Anxiolytic-like and antidepressant-like effects produced by the selective 5-HT6 receptor antagonist SB-258585 after intrahippocampal administration to rats

The results obtained indicate that the hippocampus is one of the neuroanatomical sites involved in the anxiolytic-like and antidepressant-like activity of the selective 5-HT6 receptor antagonist SB-258585.



Hyperlocomotive and Discriminative Stimulus Effects of Cocaine Are Under the Control of Serotonin2C (5-HT2C) Receptors in Rat Prefrontal Cortex

The data indicate that the PFC is a brain site at which the 5-HT2CR exerts an inhibitory control over the hyperactive and discriminative stimulus effects of cocaine known to be dependent upon activation of the DA mesoaccumbens circuit.

The role of dopamine receptor subtypes in the discriminative stimulus effects of amphetamine and cocaine in rats.

A critical role of D2 receptor subtypes in the discriminative stimuli of amphetamine and cocaine in rats is indicated, as well as a less pronounced involvement of D1 and D3 subtype ligands in the effects under study.

Dopamine D1 and D2 mediation of the discriminative stimulus properties ofd-amphetamine and cocaine

The ability of both D1 and D2 antagonists to attenuate the stimulus effects ofd-amphetamine and cocaine raises the possibility that a synergistic (“enabling”) interaction between D1 or D2 receptors may modulate stimulant cues.

Locomotor and discriminative-stimulus effects of cocaine in dopamine D5 receptor knockout mice

The present data suggest an involvement of DA D5R in the locomotor stimulant effects of cocaine, and the antagonism data suggest a role of the D1 receptor in the behavioraleffects of cocaine.

2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors.

It was found that 5-HT(6) receptors accommodate small alkyl substituents at the indole 2-position and that the resulting compounds can bind with affinities comparable to that of serotonin.

Behavioral effects of selective dopaminergic compounds in rats discriminating cocaine injections.

It is suggested that both D1 and D2 receptors may play a role in the discriminative stimulus effects of cocaine but that stimulation of either dopamine receptor subtype alone is not sufficient.