Modulation of the stimulus effects of (+)amphetamine by the 5-HT6 antagonist MS-245

@article{Pullagurla2004ModulationOT,
  title={Modulation of the stimulus effects of (+)amphetamine by the 5-HT6 antagonist MS-245},
  author={Manik Reddy Pullagurla and Tatiana S Bondareva and Richard Young and Richard A Glennon},
  journal={Pharmacology Biochemistry and Behavior},
  year={2004},
  volume={78},
  pages={263-268}
}
5-HT(6) serotonin receptors are distributed within some dopamine terminal regions in the brain leading to suggestions that they might influence dopaminergic function. In the present study, the 5-HT(6) antagonist 5-methoxy-N,N-dimethyl-N(1)-benzenesulfonyltryptamine (MS-245) was without effect when administered (3.0-7.5 mg/kg) to rats trained to discriminate (+)amphetamine (1.0 mg/kg) from saline vehicle in a two-lever drug discrimination task. Administered in combination, 0.3 mg/kg (i.e., the… Expand
The 5-HT3 receptor partial agonist MD-354 (meta-chlorophenylguanidine) enhances the discriminative stimulus actions of (+)amphetamine in rats
TLDR
It is concluded that even though MD-354 lacks amphetamine-like central stimulant actions of its own it can modulate the discriminative stimulus effects of (+)amphetamine in rats. Expand
Effect of the 5-HT6 serotonin antagonist MS-245 on the actions of (−)nicotine
TLDR
The 5-HT(6) serotonin receptor antagonist MS-245 was shown to enhance the potency of (-)nicotine in Sprague-Dawley rats trained to discriminate from saline vehicle, and possible involvement of serotonin-regulated signaling mechanisms in certain behavioral effects of nicotine is suggested. Expand
Effects of serotonin (5-HT)6 receptor ligands on responding for cocaine reward and seeking in rats.
TLDR
The results indicate that the selective pharmacological blockade or activation of 5-HT(6) receptors altered the maintenance of cocaine self-administration as well as cocaine-evoked reinstatement of cocaine seeking and expression of cocaine place preference in rats. Expand
The selective 5-HT(6) receptor antagonist SB-399885 enhances anti-immobility action of antidepressants in rats.
TLDR
The obtained results indicate that the blockade of 5-HT(6) receptors may facilitate the anti-immobility effect of imipramine, desipramsine, bupropion or moclobemide in the forced swim test. Expand
Study into a possible mechanism responsible for the antidepressant-like activity of the selective 5-HT6 receptor antagonist SB-399885 in rats.
TLDR
The results described in the present paper indicate that the anti-immobility activity of SB-399885 is not connected with 5-HT innervation, and that D(1)- and D(2-like receptors and alpha(2)-adrenoceptors are involved in this action. Expand
Evidence for a role of a dopamine/5-HT6 receptor interaction in cocaine reinforcement
TLDR
It is suggested that 5-HT6 receptors play a role in cocaine reinforcement via their facilitatory interaction with DA projections to the NAc shell and might provide the basis for a new pharmacotherapeutic strategy of cocaine addiction. Expand
An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function
  • K. Fone
  • Medicine, Psychology
  • Neuropharmacology
  • 2008
TLDR
Both 5-HT(6) receptor agonist and antagonist compounds show promise as pro-cognitive agents in pre-clinical studies but the explanation for their paradoxical analogous effect is currently unclear, and is discussed in this article. Expand
Determining the region-specific contributions of 5-HT receptors to the psychostimulant effects of cocaine.
TLDR
Which subtypes regulate behaviours that are related to cocaine addiction and how they might provide new therapeutic approaches are described to provide a new receptor-based approach for understanding the 5-HT mechanisms that subserve the actions of cocaine and possible pharmacotherapies against cocaine addiction. Expand
Impact of regional 5-HT depletion on the cognitive enhancing effects of a typical 5-ht6 receptor antagonist, Ro 04-6790, in the Novel Object Discrimination task
TLDR
The ability of Ro 04-6790 to prolong object recognition memory requires blockade of MR 5-HT function, and widespread LV or selective MR, but not DR lesions, abolished the ability to delay natural forgetting. Expand
Anxiolytic-like and antidepressant-like effects produced by the selective 5-HT6 receptor antagonist SB-258585 after intrahippocampal administration to rats
TLDR
The results obtained indicate that the hippocampus is one of the neuroanatomical sites involved in the anxiolytic-like and antidepressant-like activity of the selective 5-HT6 receptor antagonist SB-258585. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 27 REFERENCES
Potentiation of amphetamine-induced changes in dopamine and 5-HT by a 5-HT6 receptor antagonist
TLDR
Data indicate that the 5-HT(6) receptor is not playing a role in the tonic modulation of NA, DA, 5- HT or glutamate neurotransmission in the striatum, however, when dopaminergic neurotransmission is enhanced the5- HT( 6) receptor appears to have a modulatory influence on not only DA but also 5-hydroxytryptamine systems. Expand
Hyperlocomotive and Discriminative Stimulus Effects of Cocaine Are Under the Control of Serotonin2C (5-HT2C) Receptors in Rat Prefrontal Cortex
TLDR
The data indicate that the PFC is a brain site at which the 5-HT2CR exerts an inhibitory control over the hyperactive and discriminative stimulus effects of cocaine known to be dependent upon activation of the DA mesoaccumbens circuit. Expand
Effects of stimulation and blockade of dopamine receptor subtypes on the discriminative stimulus properties of cocaine
TLDR
The data suggest that the involvement of DA systems in the behavioral effects of cocaine is more complex than either D1or D2 receptor activation; for example, the stimulus properties of this substance might involve both D1and D2 receptors activation. Expand
5-HT6 receptor antagonism potentiates the behavioral and neurochemical effects of amphetamine but not cocaine
TLDR
The effects of a novel 5-HT(6) receptor antagonist, SB 258510A, on psychostimulant-induced motor activity, self-administration, and increases in extracellular dopamine in the nucleus accumbens and frontal cortex of male Wistar rats are characterized. Expand
The role of dopamine receptor subtypes in the discriminative stimulus effects of amphetamine and cocaine in rats.
TLDR
A critical role of D2 receptor subtypes in the discriminative stimuli of amphetamine and cocaine in rats is indicated, as well as a less pronounced involvement of D1 and D3 subtype ligands in the effects under study. Expand
The dopamine D4 receptor antagonist L-745,870: effects in rats discriminating cocaine from saline.
TLDR
It is suggested that dopamine D4 receptors play a negligible role in cocaine's discriminative stimulus effects, and a critical involvement of dopamine D1-like receptors is supported. Expand
Dopamine D1 and D2 mediation of the discriminative stimulus properties ofd-amphetamine and cocaine
TLDR
The ability of both D1 and D2 antagonists to attenuate the stimulus effects ofd-amphetamine and cocaine raises the possibility that a synergistic (“enabling”) interaction between D1 or D2 receptors may modulate stimulant cues. Expand
Cocaine-stimulus generalization to two new designer drugs: Methcathinone and 4-methylaminorex
Rats were trained to discriminate 8 mg/kg cocaine from saline vehicle for the purpose of examining the stimulus properties of two novel and structurally related drugs of abuse recently confiscated onExpand
Locomotor and discriminative-stimulus effects of cocaine in dopamine D5 receptor knockout mice
TLDR
The present data suggest an involvement of DA D5R in the locomotor stimulant effects of cocaine, and the antagonism data suggest a role of the D1 receptor in the behavioraleffects of cocaine. Expand
Modulation of cocaine's discriminative stimulus effects by dopamine D1 agonists in rhesus monkeys
TLDR
Results indicate that D(1) agonists have cocaine-like discriminative stimulus effects in rhesus monkeys that are consistent with their in vitro efficacies, however, when given in combination with cocaine, D( 1) agonist efficacy does not appear to be a major factor in modifying cocaine's discriminatives stimulus effects. Expand
...
1
2
3
...