Modulation of the sigma-1 receptor–IRE1 pathway is beneficial in preclinical models of inflammation and sepsis

  title={Modulation of the sigma-1 receptor–IRE1 pathway is beneficial in preclinical models of inflammation and sepsis},
  author={Dorian A Rosen and Scott M. Seki and Anthony Fern{\'a}ndez-Casta{\~n}eda and Rebecca M. Beiter and Jacob D. Eccles and Judith A. Woodfolk and Alban Gaultier},
  journal={Science Translational Medicine},
Sigma-1 receptor is a critical inhibitor of endoplasmic reticulum–driven inflammation and a potential therapeutic target in septic shock. Sigma-1 receptor subdues systemic inflammation Systemic inflammation can be lethal, as in the case of septic shock. Rosen et al. hypothesized that the endoplasmic reticulum, now understood to affect inflammation, could be an untapped therapeutic target. They found that mice lacking the endoplasmic reticulum sigma-1 receptor had exacerbated responses to LPS or… 
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Repurposing Sigma-1 Receptor Ligands for COVID-19 Therapy?
  • J. Vela
  • Biology
    Frontiers in Pharmacology
  • 2020
Targeting Sig-1R is not expected to reduce dramatically established viral replication, but it might interfere with early steps of virus-induced host cell reprogramming, aid to slow down the course of infection, prevent the aggravation of the disease and/or allow a time window to mature a protective immune response.
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Current Murine Models of Sepsis.
The idea that a perfect murine model of sepsis exists is untenable, but a variety of good options for modeling exist depending on the focus of the research, and a focus on methodology, common variations, issues, and limitations is summarized.
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