Modulation of the renin-angiotensin pathway through enzyme inhibition and specific receptor blockade in pacing-induced heart failure: II. Effects on myocyte contractile processes.

@article{Spinale1997ModulationOT,
  title={Modulation of the renin-angiotensin pathway through enzyme inhibition and specific receptor blockade in pacing-induced heart failure: II. Effects on myocyte contractile processes.},
  author={Francis G. Spinale and Rupak Mukherjee and Julie P. Iannini and S E Whitebread and Latha Hebbar and Mark J. Clair and Dustin Melton and Montgomery H Cox and Patrick B. Thomas and Marc de Gasparo},
  journal={Circulation},
  year={1997},
  volume={96 7},
  pages={2397-406}
}
BACKGROUND The goal of this study was to determine the effects of ACE inhibition alone, AT1 angiotensin (Ang) II receptor blockade alone, and combined ACEI and AT1 Ang II receptor blockade in a model of congestive heart failure (CHF) on isolated LV myocyte function and fundamental components of the excitation-contraction coupling process. METHODS AND RESULTS Pigs were randomly assigned to one of five groups: (1) rapid atrial pacing (240 bpm) for 3 weeks (n=9), (2) concomitant ACEI… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

Similar Papers

Loading similar papers…