Modulation of the renin-angiotensin pathway through enzyme inhibition and specific receptor blockade in pacing-induced heart failure: I. Effects on left ventricular performance and neurohormonal systems.

@article{Spinale1997ModulationOT,
  title={Modulation of the renin-angiotensin pathway through enzyme inhibition and specific receptor blockade in pacing-induced heart failure: I. Effects on left ventricular performance and neurohormonal systems.},
  author={Francis G. Spinale and Marc de Gasparo and Steve Whitebread and Latha Hebbar and Mark J. Clair and David Michael Melton and R. Stephen Krombach and Rupak Mukherjee and Julie P. Iannini and O Smith},
  journal={Circulation},
  year={1997},
  volume={96 7},
  pages={
          2385-96
        }
}
BACKGROUND The goal of this study was to determine the effects of ACE inhibition (ACEI) alone, AT1 angiotensin (Ang) II receptor blockade alone, and combined ACEI and AT1 Ang II receptor blockade on LV function, systemic hemodynamics, and neurohormonal system activity in a model of congestive heart failure (CHF). METHODS AND RESULTS Pigs were randomly assigned to each of 5 groups: (1) rapid atrial pacing (240 bpm) for 3 weeks (n=9), (2) ACEI (benazeprilat, 0.187 mg x kg(-1) x d(-1)) and rapid… CONTINUE READING
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