Modulation of the rat suprachiasmatic circadian clock by melatonin in vitro.

  title={Modulation of the rat suprachiasmatic circadian clock by melatonin in vitro.},
  author={Sarah J. Starkey and Matthew P. Walker and Isabel J Beresford and Russell M. Hagan},
  volume={6 14},
The pineal hormone melatonin regulates daily and seasonal rhythms, at least in part through an action on the mammalian biological clock in the suprachiasmatic nuclei (SCN). Melatonin was tested in vitro (10(-15)-10(-6) M; ZT9.5-10.5) for its effect on the circadian peak in neuronal firing rate in the rat SCN slice. It produced a concentration-related phase advance (maximum advance = 3 +/- 0.3 h at 10(-9) M, n = 3; minimum effective concentration = 10(-13) M; EC50 = 1.2 x 10(-12) M). The… CONTINUE READING

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